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Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer

Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. CGB is encoded by a cluster of six genes, of which type II genes (CGB3/9, 5 and 8) have been shown to be upregulated in relation to type I genes (CGB6/7) in both placentas a...

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Autores principales: Kubiczak, Marta, Walkowiak, Grzegorz P., Nowak-Markwitz, Ewa, Jankowska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709805/
https://www.ncbi.nlm.nih.gov/pubmed/23774837
http://dx.doi.org/10.3390/ijms140612650
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author Kubiczak, Marta
Walkowiak, Grzegorz P.
Nowak-Markwitz, Ewa
Jankowska, Anna
author_facet Kubiczak, Marta
Walkowiak, Grzegorz P.
Nowak-Markwitz, Ewa
Jankowska, Anna
author_sort Kubiczak, Marta
collection PubMed
description Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. CGB is encoded by a cluster of six genes, of which type II genes (CGB3/9, 5 and 8) have been shown to be upregulated in relation to type I genes (CGB6/7) in both placentas and tumors. Recent studies revealed that CGB1 and CGB2, originally considered as pseudogenes, might also be active, however, the protein products of these genes have not yet been identified. Our study demonstrates the presence of CGB1 and CGB2 transcripts in ovarian carcinomas. While CGB1 and CGB2 gene activation was not detected in normal ovaries lacking cancerous development, our study demonstrates the presence of CGB1 and CGB2 transcripts in 41% of analyzed ovarian cancer cases.
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spelling pubmed-37098052013-07-12 Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer Kubiczak, Marta Walkowiak, Grzegorz P. Nowak-Markwitz, Ewa Jankowska, Anna Int J Mol Sci Article Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. CGB is encoded by a cluster of six genes, of which type II genes (CGB3/9, 5 and 8) have been shown to be upregulated in relation to type I genes (CGB6/7) in both placentas and tumors. Recent studies revealed that CGB1 and CGB2, originally considered as pseudogenes, might also be active, however, the protein products of these genes have not yet been identified. Our study demonstrates the presence of CGB1 and CGB2 transcripts in ovarian carcinomas. While CGB1 and CGB2 gene activation was not detected in normal ovaries lacking cancerous development, our study demonstrates the presence of CGB1 and CGB2 transcripts in 41% of analyzed ovarian cancer cases. Molecular Diversity Preservation International (MDPI) 2013-06-17 /pmc/articles/PMC3709805/ /pubmed/23774837 http://dx.doi.org/10.3390/ijms140612650 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kubiczak, Marta
Walkowiak, Grzegorz P.
Nowak-Markwitz, Ewa
Jankowska, Anna
Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer
title Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer
title_full Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer
title_fullStr Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer
title_full_unstemmed Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer
title_short Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer
title_sort human chorionic gonadotropin beta subunit genes cgb1 and cgb2 are transcriptionally active in ovarian cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709805/
https://www.ncbi.nlm.nih.gov/pubmed/23774837
http://dx.doi.org/10.3390/ijms140612650
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