The Synthetic Amphipathic Peptidomimetic LTX109 Is a Potent Fungicide That Disturbs Plasma Membrane Integrity in a Sphingolipid Dependent Manner

The peptidomimetic LTX109 (arginine-tertbutyl tryptophan-arginine-phenylethan) was previously shown to have antibacterial properties. Here, we investigated the activity of this novel antimicrobial peptidomimetic on the yeast Saccharomyces cerevisiae. We found that LTX109 was an efficient fungicide t...

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Detalles Bibliográficos
Autores principales: Bojsen, Rasmus, Torbensen, Rasmus, Larsen, Camilla Eggert, Folkesson, Anders, Regenberg, Birgitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709891/
https://www.ncbi.nlm.nih.gov/pubmed/23874964
http://dx.doi.org/10.1371/journal.pone.0069483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709891/
https://www.ncbi.nlm.nih.gov/pubmed/23874964
http://dx.doi.org/10.1371/journal.pone.0069483

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