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Adjudin disrupts spermatogenesis by targeting drug transporters: Lesson from the breast cancer resistance protein (BCRP)
For non-hormonal male contraceptives that exert their effects in the testis locally instead of via the hypothalamic-pituitary-testicular axis, such as adjudin that disrupts germ cell adhesion, a major hurdle in their development is to improve their bioavailability so that they can be efficiently del...
Autores principales: | Qian, Xiaojing, Cheng, Yan-ho, Jenardhanan, Pranitha, Mruk, Dolores D., Mathur, Premendu P., Xia, Weiliang, Silvestrini, Bruno, Cheng, C. Yan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710224/ https://www.ncbi.nlm.nih.gov/pubmed/23885306 http://dx.doi.org/10.4161/spmg.24993 |
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