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Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection

BACKGROUND: Enterovirus 71 (EV71) infections are associated with a high prevalence of hand, foot and mouth disease (HFMD) in children and occasionally cause lethal complications. Most infections are self-limiting. However, resulting complications, including aseptic meningitis, encephalitis, poliomye...

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Autores principales: Xiu, Jing-hui, Zhu, Hao, Xu, Yan-feng, Liu, Jiang-ning, Xia, Xian-zhu, Zhang, Lian-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710232/
https://www.ncbi.nlm.nih.gov/pubmed/23809248
http://dx.doi.org/10.1186/1743-422X-10-215
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author Xiu, Jing-hui
Zhu, Hao
Xu, Yan-feng
Liu, Jiang-ning
Xia, Xian-zhu
Zhang, Lian-feng
author_facet Xiu, Jing-hui
Zhu, Hao
Xu, Yan-feng
Liu, Jiang-ning
Xia, Xian-zhu
Zhang, Lian-feng
author_sort Xiu, Jing-hui
collection PubMed
description BACKGROUND: Enterovirus 71 (EV71) infections are associated with a high prevalence of hand, foot and mouth disease (HFMD) in children and occasionally cause lethal complications. Most infections are self-limiting. However, resulting complications, including aseptic meningitis, encephalitis, poliomyelitis-like acute flaccid paralysis, and neurological pulmonary edema or hemorrhage, are responsible for the lethal symptoms of EV71 infection, the pathogenesis of which remain to be clarified. RESULTS: In the present study, 2-week-old Institute of Cancer Research (ICR) mice were infected with a mouse-adapted EV71 strain. These infected mice demonstrated progressive paralysis and died within 12 days post infection (d.p.i.). EV71, which mainly replicates in skeletal muscle tissues, caused severe necrotizing myositis. Lesions in the central nervous system (CNS) and other tissues were not observed. CONCLUSIONS: Necrotizing myositis of respiratory-related muscles caused severe restrictive hypoventilation and subsequent hypoxia, which could explain the fatality of EV71-infected mice. This finding suggests that, in addition to CNS injury, necrotic myositis may also be responsible for the paralysis and death observed in EV71-infected mice.
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spelling pubmed-37102322013-07-13 Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection Xiu, Jing-hui Zhu, Hao Xu, Yan-feng Liu, Jiang-ning Xia, Xian-zhu Zhang, Lian-feng Virol J Research BACKGROUND: Enterovirus 71 (EV71) infections are associated with a high prevalence of hand, foot and mouth disease (HFMD) in children and occasionally cause lethal complications. Most infections are self-limiting. However, resulting complications, including aseptic meningitis, encephalitis, poliomyelitis-like acute flaccid paralysis, and neurological pulmonary edema or hemorrhage, are responsible for the lethal symptoms of EV71 infection, the pathogenesis of which remain to be clarified. RESULTS: In the present study, 2-week-old Institute of Cancer Research (ICR) mice were infected with a mouse-adapted EV71 strain. These infected mice demonstrated progressive paralysis and died within 12 days post infection (d.p.i.). EV71, which mainly replicates in skeletal muscle tissues, caused severe necrotizing myositis. Lesions in the central nervous system (CNS) and other tissues were not observed. CONCLUSIONS: Necrotizing myositis of respiratory-related muscles caused severe restrictive hypoventilation and subsequent hypoxia, which could explain the fatality of EV71-infected mice. This finding suggests that, in addition to CNS injury, necrotic myositis may also be responsible for the paralysis and death observed in EV71-infected mice. BioMed Central 2013-06-28 /pmc/articles/PMC3710232/ /pubmed/23809248 http://dx.doi.org/10.1186/1743-422X-10-215 Text en Copyright ©2013 Xiu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Xiu, Jing-hui
Zhu, Hao
Xu, Yan-feng
Liu, Jiang-ning
Xia, Xian-zhu
Zhang, Lian-feng
Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection
title Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection
title_full Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection
title_fullStr Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection
title_full_unstemmed Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection
title_short Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection
title_sort necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710232/
https://www.ncbi.nlm.nih.gov/pubmed/23809248
http://dx.doi.org/10.1186/1743-422X-10-215
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