Langerhans-type and monocyte-derived human dendritic cells have different susceptibilities to mRNA electroporation with distinct effects on maturation and activation: implications for immunogenicity in dendritic cell-based immunotherapy

BACKGROUND: mRNA electroporation of dendritic cells (DCs) facilitates processing and presentation of multiple peptides derived from whole antigen, tailored to different HLA molecules. Clinical responses to electroporated moDC vaccines, however, have been suboptimal. Human Langerhans-type DCs (LCs) a...

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Detalles Bibliográficos
Autores principales: Chung, David J, Romano, Emanuela, Pronschinske, Katherine B, Shyer, Justin A, Mennecozzi, Milena, Angelo, Erin T St, Young, James W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710267/
https://www.ncbi.nlm.nih.gov/pubmed/23837662
http://dx.doi.org/10.1186/1479-5876-11-166

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