Egr2 and Egr3 are the unique regulators for systemic autoimmunity

Systemic autoimmunity is characterized by widespread inflammation, autoantibody production and immune complex deposition. The regulatory mechanisms for the systemic autoimmunity are not fully understood. A paper by Li et al. revealed that Egr2 and Egr3, transcription factors required for T-cell aner...

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Autores principales: Sumitomo, Shuji, Fujio, Keishi, Okamura, Tomohisa, Yamamoto, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710327/
https://www.ncbi.nlm.nih.gov/pubmed/24058814
http://dx.doi.org/10.4161/jkst.23952
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author Sumitomo, Shuji
Fujio, Keishi
Okamura, Tomohisa
Yamamoto, Kazuhiko
author_facet Sumitomo, Shuji
Fujio, Keishi
Okamura, Tomohisa
Yamamoto, Kazuhiko
author_sort Sumitomo, Shuji
collection PubMed
description Systemic autoimmunity is characterized by widespread inflammation, autoantibody production and immune complex deposition. The regulatory mechanisms for the systemic autoimmunity are not fully understood. A paper by Li et al. revealed that Egr2 and Egr3, transcription factors required for T-cell anergy, are the regulators for systemic autoimmune disease. They showed evidence that Egr2 and Egr3 control cytokine productions and cell proliferation via SOCS and Batf regulation.
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spelling pubmed-37103272013-09-19 Egr2 and Egr3 are the unique regulators for systemic autoimmunity Sumitomo, Shuji Fujio, Keishi Okamura, Tomohisa Yamamoto, Kazuhiko JAKSTAT Commentary Systemic autoimmunity is characterized by widespread inflammation, autoantibody production and immune complex deposition. The regulatory mechanisms for the systemic autoimmunity are not fully understood. A paper by Li et al. revealed that Egr2 and Egr3, transcription factors required for T-cell anergy, are the regulators for systemic autoimmune disease. They showed evidence that Egr2 and Egr3 control cytokine productions and cell proliferation via SOCS and Batf regulation. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3710327/ /pubmed/24058814 http://dx.doi.org/10.4161/jkst.23952 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Sumitomo, Shuji
Fujio, Keishi
Okamura, Tomohisa
Yamamoto, Kazuhiko
Egr2 and Egr3 are the unique regulators for systemic autoimmunity
title Egr2 and Egr3 are the unique regulators for systemic autoimmunity
title_full Egr2 and Egr3 are the unique regulators for systemic autoimmunity
title_fullStr Egr2 and Egr3 are the unique regulators for systemic autoimmunity
title_full_unstemmed Egr2 and Egr3 are the unique regulators for systemic autoimmunity
title_short Egr2 and Egr3 are the unique regulators for systemic autoimmunity
title_sort egr2 and egr3 are the unique regulators for systemic autoimmunity
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710327/
https://www.ncbi.nlm.nih.gov/pubmed/24058814
http://dx.doi.org/10.4161/jkst.23952
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