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Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response

Certain bacterial pathogens are able to evade the host immune system and persist within the human host. The consequences of persistent bacterial infections potentially include increased morbidity and mortality from the infection itself as well as an increased risk of dissemination of disease. Eradic...

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Autores principales: Grant, Sarah Schmidt, Hung, Deborah T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710330/
https://www.ncbi.nlm.nih.gov/pubmed/23563389
http://dx.doi.org/10.4161/viru.23987
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author Grant, Sarah Schmidt
Hung, Deborah T.
author_facet Grant, Sarah Schmidt
Hung, Deborah T.
author_sort Grant, Sarah Schmidt
collection PubMed
description Certain bacterial pathogens are able to evade the host immune system and persist within the human host. The consequences of persistent bacterial infections potentially include increased morbidity and mortality from the infection itself as well as an increased risk of dissemination of disease. Eradication of persistent infections is difficult, often requiring prolonged or repeated courses of antibiotics. During persistent infections, a population or subpopulation of bacteria exists that is refractory to traditional antibiotics, possibly in a non-replicating or metabolically altered state. This review highlights the clinical significance of persistent infections and discusses different in vitro models used to investigate the altered physiology of bacteria during persistent infections. We specifically focus on recent work establishing increased protection against oxidative stress as a key element of the altered physiologic state across different in vitro models and pathogens.
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spelling pubmed-37103302013-07-24 Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response Grant, Sarah Schmidt Hung, Deborah T. Virulence Review Certain bacterial pathogens are able to evade the host immune system and persist within the human host. The consequences of persistent bacterial infections potentially include increased morbidity and mortality from the infection itself as well as an increased risk of dissemination of disease. Eradication of persistent infections is difficult, often requiring prolonged or repeated courses of antibiotics. During persistent infections, a population or subpopulation of bacteria exists that is refractory to traditional antibiotics, possibly in a non-replicating or metabolically altered state. This review highlights the clinical significance of persistent infections and discusses different in vitro models used to investigate the altered physiology of bacteria during persistent infections. We specifically focus on recent work establishing increased protection against oxidative stress as a key element of the altered physiologic state across different in vitro models and pathogens. Landes Bioscience 2013-05-15 2013-04-05 /pmc/articles/PMC3710330/ /pubmed/23563389 http://dx.doi.org/10.4161/viru.23987 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Grant, Sarah Schmidt
Hung, Deborah T.
Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response
title Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response
title_full Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response
title_fullStr Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response
title_full_unstemmed Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response
title_short Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response
title_sort persistent bacterial infections, antibiotic tolerance, and the oxidative stress response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710330/
https://www.ncbi.nlm.nih.gov/pubmed/23563389
http://dx.doi.org/10.4161/viru.23987
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