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Comparison between bacteremia caused by carbapenem resistant Acinetobacter baumannii and Acinetobacter nosocomialis
BACKGROUND: It is unknown whether there are differences between bacteremia caused by carbapenem resistant Acinetobacter baumannii (CRAB) and carbapenem resistant Acinetobacter nosocomialis (CRAN). This study aims to investigate the differences, especially in clinical outcomes, between patients with...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710499/ https://www.ncbi.nlm.nih.gov/pubmed/23841753 http://dx.doi.org/10.1186/1471-2334-13-311 |
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author | Yang, Ya-Sung Lee, Yi-Tzu Tsai, Wen-Chiuan Kuo, Shu-Chen Sun, Jun-Ren Yang, Chin-Hsuan Chen, Te-Li Lin, Jung-Chung Fung, Chang-Phone Chang, Feng-Yee |
author_facet | Yang, Ya-Sung Lee, Yi-Tzu Tsai, Wen-Chiuan Kuo, Shu-Chen Sun, Jun-Ren Yang, Chin-Hsuan Chen, Te-Li Lin, Jung-Chung Fung, Chang-Phone Chang, Feng-Yee |
author_sort | Yang, Ya-Sung |
collection | PubMed |
description | BACKGROUND: It is unknown whether there are differences between bacteremia caused by carbapenem resistant Acinetobacter baumannii (CRAB) and carbapenem resistant Acinetobacter nosocomialis (CRAN). This study aims to investigate the differences, especially in clinical outcomes, between patients with bacteremia caused by CRAB or CRAN. METHODS: This is a 9-year retrospective study comparing the clinical manifestations, antimicrobial susceptibilities, and clinical outcomes of 71 patients with CRAB bacteremia and 64 patients with CRAN bacteremia. RESULTS: Patients with CRAB were more likely to have hematologic malignancies and presented with more shock episodes than those with CRAN. CRAB isolates were more resistant to various classes of antimicrobials except colistin, and therefore the patients with CRAB bacteremia were more likely to receive inappropriate antimicrobial therapies. The 14-day mortality was significantly higher in patients with CRAB (40.8% vs. 14.1%; p = 0.001), and in this study, acquisition of CRAB was identified as an independent risk factor for mortality (odds ratio = 4.003; 95% confidence interval = 1.566-10.231; p = 0.004). CONCLUSIONS: CRAB and CRAN bacteremia are different in clinical characteristics, antimicrobial susceptibilities, and mortality rates. Genomic species identification should be performed in the study of carbapenem resistant Acinetobacters to better delineate the role of different species. |
format | Online Article Text |
id | pubmed-3710499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-37104992013-07-14 Comparison between bacteremia caused by carbapenem resistant Acinetobacter baumannii and Acinetobacter nosocomialis Yang, Ya-Sung Lee, Yi-Tzu Tsai, Wen-Chiuan Kuo, Shu-Chen Sun, Jun-Ren Yang, Chin-Hsuan Chen, Te-Li Lin, Jung-Chung Fung, Chang-Phone Chang, Feng-Yee BMC Infect Dis Research Article BACKGROUND: It is unknown whether there are differences between bacteremia caused by carbapenem resistant Acinetobacter baumannii (CRAB) and carbapenem resistant Acinetobacter nosocomialis (CRAN). This study aims to investigate the differences, especially in clinical outcomes, between patients with bacteremia caused by CRAB or CRAN. METHODS: This is a 9-year retrospective study comparing the clinical manifestations, antimicrobial susceptibilities, and clinical outcomes of 71 patients with CRAB bacteremia and 64 patients with CRAN bacteremia. RESULTS: Patients with CRAB were more likely to have hematologic malignancies and presented with more shock episodes than those with CRAN. CRAB isolates were more resistant to various classes of antimicrobials except colistin, and therefore the patients with CRAB bacteremia were more likely to receive inappropriate antimicrobial therapies. The 14-day mortality was significantly higher in patients with CRAB (40.8% vs. 14.1%; p = 0.001), and in this study, acquisition of CRAB was identified as an independent risk factor for mortality (odds ratio = 4.003; 95% confidence interval = 1.566-10.231; p = 0.004). CONCLUSIONS: CRAB and CRAN bacteremia are different in clinical characteristics, antimicrobial susceptibilities, and mortality rates. Genomic species identification should be performed in the study of carbapenem resistant Acinetobacters to better delineate the role of different species. BioMed Central 2013-07-10 /pmc/articles/PMC3710499/ /pubmed/23841753 http://dx.doi.org/10.1186/1471-2334-13-311 Text en Copyright © 2013 Yang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yang, Ya-Sung Lee, Yi-Tzu Tsai, Wen-Chiuan Kuo, Shu-Chen Sun, Jun-Ren Yang, Chin-Hsuan Chen, Te-Li Lin, Jung-Chung Fung, Chang-Phone Chang, Feng-Yee Comparison between bacteremia caused by carbapenem resistant Acinetobacter baumannii and Acinetobacter nosocomialis |
title | Comparison between bacteremia caused by carbapenem resistant Acinetobacter baumannii and Acinetobacter nosocomialis |
title_full | Comparison between bacteremia caused by carbapenem resistant Acinetobacter baumannii and Acinetobacter nosocomialis |
title_fullStr | Comparison between bacteremia caused by carbapenem resistant Acinetobacter baumannii and Acinetobacter nosocomialis |
title_full_unstemmed | Comparison between bacteremia caused by carbapenem resistant Acinetobacter baumannii and Acinetobacter nosocomialis |
title_short | Comparison between bacteremia caused by carbapenem resistant Acinetobacter baumannii and Acinetobacter nosocomialis |
title_sort | comparison between bacteremia caused by carbapenem resistant acinetobacter baumannii and acinetobacter nosocomialis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710499/ https://www.ncbi.nlm.nih.gov/pubmed/23841753 http://dx.doi.org/10.1186/1471-2334-13-311 |
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