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Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa

The gastric epithelium is protected from the highly acidic luminal content by alkaline mucus which is secreted from specialized epithelial cells. In the stomach of mice strong secretion of alkaline fluid was observed at the “gastric groove,” the border between corpus and fundus mucosa. Since this re...

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Autores principales: Eberle, Julia Anna-Maria, Müller-Roth, Kai L., Widmayer, Patricia, Chubanov, Vladimir, Gudermann, Thomas, Breer, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711009/
https://www.ncbi.nlm.nih.gov/pubmed/23874305
http://dx.doi.org/10.3389/fphys.2013.00182
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author Eberle, Julia Anna-Maria
Müller-Roth, Kai L.
Widmayer, Patricia
Chubanov, Vladimir
Gudermann, Thomas
Breer, Heinz
author_facet Eberle, Julia Anna-Maria
Müller-Roth, Kai L.
Widmayer, Patricia
Chubanov, Vladimir
Gudermann, Thomas
Breer, Heinz
author_sort Eberle, Julia Anna-Maria
collection PubMed
description The gastric epithelium is protected from the highly acidic luminal content by alkaline mucus which is secreted from specialized epithelial cells. In the stomach of mice strong secretion of alkaline fluid was observed at the “gastric groove,” the border between corpus and fundus mucosa. Since this region is characterized by numerous brush cells it was proposed that these cells might secrete alkaline solution as suggested for brush cells in the bile duct. In fact, it was found that in this region multiple cells express elements which are relevant for the secretion of bicarbonate, including carbonic anhydrase (CAII), the cystic fibrosis transmembrane conductance regulator (CFTR) and the Na(+)/H(+) exchanger (NHE1). However, this cell population was distinct from brush cells which express the TRP-channel TRPM5 and are considered as putative sensory cells. The location of both cell populations in close proximity implies the possibility for a paracrine interaction. This view was substantiated by the finding that brush cells express prostaglandin synthase-1 (COX-1) and the neighboring cells a specific receptor type for prostaglandins. The notion that brush cells may be able to sense a local acidification was supported by the observation that they express the channel PKD1L3 which contributes to the acid responsiveness of gustatory sensory cells. The results support the concept that brush cells may sense the luminal content and influence via prostaglandins the secretion of alkaline solution.
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spelling pubmed-37110092013-07-19 Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa Eberle, Julia Anna-Maria Müller-Roth, Kai L. Widmayer, Patricia Chubanov, Vladimir Gudermann, Thomas Breer, Heinz Front Physiol Physiology The gastric epithelium is protected from the highly acidic luminal content by alkaline mucus which is secreted from specialized epithelial cells. In the stomach of mice strong secretion of alkaline fluid was observed at the “gastric groove,” the border between corpus and fundus mucosa. Since this region is characterized by numerous brush cells it was proposed that these cells might secrete alkaline solution as suggested for brush cells in the bile duct. In fact, it was found that in this region multiple cells express elements which are relevant for the secretion of bicarbonate, including carbonic anhydrase (CAII), the cystic fibrosis transmembrane conductance regulator (CFTR) and the Na(+)/H(+) exchanger (NHE1). However, this cell population was distinct from brush cells which express the TRP-channel TRPM5 and are considered as putative sensory cells. The location of both cell populations in close proximity implies the possibility for a paracrine interaction. This view was substantiated by the finding that brush cells express prostaglandin synthase-1 (COX-1) and the neighboring cells a specific receptor type for prostaglandins. The notion that brush cells may be able to sense a local acidification was supported by the observation that they express the channel PKD1L3 which contributes to the acid responsiveness of gustatory sensory cells. The results support the concept that brush cells may sense the luminal content and influence via prostaglandins the secretion of alkaline solution. Frontiers Media S.A. 2013-07-15 /pmc/articles/PMC3711009/ /pubmed/23874305 http://dx.doi.org/10.3389/fphys.2013.00182 Text en Copyright © 2013 Eberle, Müller-Roth, Widmayer, Chubanov, Gudermann and Breer. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Physiology
Eberle, Julia Anna-Maria
Müller-Roth, Kai L.
Widmayer, Patricia
Chubanov, Vladimir
Gudermann, Thomas
Breer, Heinz
Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa
title Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa
title_full Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa
title_fullStr Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa
title_full_unstemmed Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa
title_short Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa
title_sort putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711009/
https://www.ncbi.nlm.nih.gov/pubmed/23874305
http://dx.doi.org/10.3389/fphys.2013.00182
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