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Efficacy of Histone Deacetylase and Estrogen Receptor Inhibition in Breast Cancer Cells Due to Concerted down Regulation of Akt

Hormonal therapy resistance remains a considerable barrier in the treatment of breast cancer. Activation of the Akt-PI3K-mTOR pathway plays an important role in hormonal therapy resistance. Our recent preclinical and clinical studies showed that the addition of a histone deacetylase inhibitor re-sen...

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Detalles Bibliográficos
Autores principales:	Thomas, Scott, Thurn, K. Ted, Raha, Paromita, Chen, Stephanie, Munster, Pamela N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711340/ https://www.ncbi.nlm.nih.gov/pubmed/23874830 http://dx.doi.org/10.1371/journal.pone.0068973

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