A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy

Scalable and efficient production of high-quality recombinant adeno-associated virus (rAAV) for gene therapy remains a challenge despite recent clinical successes. We developed a new strategy for scalable and efficient rAAV production by sequestering the AAV helper genes and the rAAV vector DNA in t...

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Detalles Bibliográficos
Autores principales: Dong, Biao, Moore, Andrea R., Dai, Jihong, Roberts, Sean, Chu, Kirk, Kapranov, Philipp, Moss, Bernard, Xiao, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711426/
https://www.ncbi.nlm.nih.gov/pubmed/23677609
http://dx.doi.org/10.1093/nar/gkt404

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