Crystal structure and functional insights into uracil-DNA glycosylase inhibition by phage ϕ29 DNA mimic protein p56

Uracil-DNA glycosylase (UDG) is a key repair enzyme responsible for removing uracil residues from DNA. Interestingly, UDG is the only enzyme known to be inhibited by two different DNA mimic proteins: p56 encoded by the Bacillus subtilis phage ϕ29 and the well-characterized protein Ugi encoded by the...

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Detalles Bibliográficos
Autores principales: Baños-Sanz, José Ignacio, Mojardín, Laura, Sanz-Aparicio, Julia, Lázaro, José M., Villar, Laurentino, Serrano-Heras, Gemma, González, Beatriz, Salas, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711442/
https://www.ncbi.nlm.nih.gov/pubmed/23671337
http://dx.doi.org/10.1093/nar/gkt395

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