Cargando…
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, we and others have found that COX-1, not COX-2, is responsible for vascula...
Autores principales: | Kirkby, Nicholas S., Zaiss, Anne K., Urquhart, Paula, Jiao, Jing, Austin, Philip J., Al-Yamani, Malak, Lundberg, Martina H., MacKenzie, Louise S., Warner, Timothy D., Nicolaou, Anna, Herschman, Harvey R., Mitchell, Jane A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711559/ https://www.ncbi.nlm.nih.gov/pubmed/23874970 http://dx.doi.org/10.1371/journal.pone.0069524 |
Ejemplares similares
-
Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox
por: Mitchell, Jane A., et al.
Publicado: (2019) -
COX-2 Protects against Atherosclerosis Independently of Local Vascular Prostacyclin: Identification of COX-2 Associated Pathways Implicate Rgl1 and Lymphocyte Networks
por: Kirkby, Nicholas S., et al.
Publicado: (2014) -
Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies()
por: Kirkby, Nicholas S., et al.
Publicado: (2013) -
Prostacyclin mediates endothelial COX-2-dependent neuroprotective effects during excitotoxic brain injury
por: An, Ying, et al.
Publicado: (2014) -
Reversible Suppression of Cyclooxygenase 2 (COX-2) Expression In Vivo by Inducible RNA Interference
por: Zaiss, Anne K., et al.
Publicado: (2014)