Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection

Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) are key anti- and pro-inflammatory mediators elicited during the host immune response to Mycobacterium tuberculosis (Mtb). Understanding the opposing effects of these mediators is difficult due to the complexity of processes acting across di...

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Detalles Bibliográficos
Autores principales: Cilfone, Nicholas A., Perry, Cory R., Kirschner, Denise E., Linderman, Jennifer J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711807/
https://www.ncbi.nlm.nih.gov/pubmed/23869227
http://dx.doi.org/10.1371/journal.pone.0068680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711807/
https://www.ncbi.nlm.nih.gov/pubmed/23869227
http://dx.doi.org/10.1371/journal.pone.0068680

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