Extracellular Signal–Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle

Leptin is a key regulator of glucose metabolism in mammals, but the mechanisms of its action have remained elusive. We now show that signaling by extracellular signal–regulated kinase (ERK) and its upstream kinase MEK in the ventromedial hypothalamus (VMH) mediates the leptin-induced increase in glu...

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Detalles Bibliográficos
Autores principales: Toda, Chitoku, Shiuchi, Tetsuya, Kageyama, Haruaki, Okamoto, Shiki, Coutinho, Eulalia A., Sato, Tatsuya, Okamatsu-Ogura, Yuko, Yokota, Shigefumi, Takagi, Kazuyo, Tang, Lijun, Saito, Kumiko, Shioda, Seiji, Minokoshi, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712028/
https://www.ncbi.nlm.nih.gov/pubmed/23530005
http://dx.doi.org/10.2337/db12-1629

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