A Novel Mechanism by Which SDF-1β Protects Cardiac Cells From Palmitate-Induced Endoplasmic Reticulum Stress and Apoptosis via CXCR7 and AMPK/p38 MAPK-Mediated Interleukin-6 Generation

We studied the protective effect of stromal cell-derived factor-1β (SDF-1β) on cardiac cells from lipotoxicity in vitro and diabetes in vivo. Exposure of cardiac cells to palmitate increased apoptosis by activating NADPH oxidase (NOX)–associated nitrosative stress and endoplasmic reticulum (ER) stre...

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Detalles Bibliográficos
Autores principales: Zhao, Yuguang, Tan, Yi, Xi, Shugang, Li, Yunqian, Li, Cai, Cui, Jiuwei, Yan, Xiaoqing, Li, Xiaokun, Wang, Guanjun, Li, Wei, Cai, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712029/
https://www.ncbi.nlm.nih.gov/pubmed/23423573
http://dx.doi.org/10.2337/db12-1233

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