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Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

We measured the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens and found that only hepatic pyruvate carboxylase protein levels related strongly with glycemia. We assessed the role of pyruvate carboxylase in regulating glucose and lipid metabolism in rats...

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Detalles Bibliográficos
Autores principales:	Kumashiro, Naoki, Beddow, Sara A., Vatner, Daniel F., Majumdar, Sachin K., Cantley, Jennifer L., Guebre-Egziabher, Fitsum, Fat, Ioana, Guigni, Blas, Jurczak, Michael J., Birkenfeld, Andreas L., Kahn, Mario, Perler, Bryce K., Puchowicz, Michelle A., Manchem, Vara Prasad, Bhanot, Sanjay, Still, Christopher D., Gerhard, Glenn S., Petersen, Kitt Falk, Cline, Gary W., Shulman, Gerald I., Samuel, Varman T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712050/ https://www.ncbi.nlm.nih.gov/pubmed/23423574 http://dx.doi.org/10.2337/db12-1311

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