Cargando…

Human Pancreatic β-Cell G1/S Molecule Cell Cycle Atlas

Expansion of pancreatic β-cells is a key goal of diabetes research, yet induction of adult human β-cell replication has proven frustratingly difficult. In part, this reflects a lack of understanding of cell cycle control in the human β-cell. Here, we provide a comprehensive immunocytochemical “atlas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fiaschi-Taesch, Nathalie M., Kleinberger, Jeffrey W., Salim, Fatimah G., Troxell, Ronnie, Wills, Rachel, Tanwir, Mansoor, Casinelli, Gabriella, Cox, Amy E., Takane, Karen K., Scott, Donald K., Stewart, Andrew F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712053/ https://www.ncbi.nlm.nih.gov/pubmed/23493570 http://dx.doi.org/10.2337/db12-0777

Ejemplares similares

Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human β-Cell Replication: A Revised Model of Human β-Cell G1/S Control
por: Fiaschi-Taesch, Nathalie M., et al.
Publicado: (2013)

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6
por: Fiaschi-Taesch, Nathalie M., et al.
Publicado: (2010)

Regulated and Reversible Induction of Adult Human β-Cell Replication
por: Takane, Karen K., et al.
Publicado: (2012)

Definition of a Skp2-c-Myc Pathway to Expand Human Beta-cells
por: Tiwari, Shiwani, et al.
Publicado: (2016)

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells
por: Chen, Hainan, et al.
Publicado: (2015)

Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines
por: Cozar-Castellano, Irene, et al.
Publicado: (2008)

Survey of the Human Pancreatic β-Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D(1) in Enhancing Human β-Cell Replication and Function In Vivo
por: Fiaschi-Taesch, Nathalie, et al.
Publicado: (2009)

Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets
por: Fiaschi-Taesch, Nathalie M., et al.
Publicado: (2008)

Breast Carcinoma After Ocrelizumab Therapy in Multiple Sclerosis Patients: A Case Series and Literature Review
por: Kelsey, Andrew, et al.
Publicado: (2021)

Mechanisms of Cancer Cell Killing by the Adenovirus E4orf4 Protein
por: Kleinberger, Tamar
Publicado: (2015)

Adhesion molecule expression and cell cycle control in cells of the immune system are sensitive to altered gravity
por: Ullrich, O, et al.
Publicado: (2009)

Diffuse-primary-B-cell lymphoma of the cranial vault presenting as stroke
por: Salvo, Vincenzo, et al.
Publicado: (2018)

Atypical anti-glomerular basement membrane disease
por: Troxell, Megan L., et al.
Publicado: (2016)

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2
por: Lakshmipathi, Jayalakshmi, et al.
Publicado: (2016)

Cell cycle, cell division, cell death
por: Maddox, Amy Shaub, et al.
Publicado: (2019)

The adenovirus E4orf4 protein induces a unique mode of cell death while inhibiting classical apoptosis
por: Pechkovsky, Antonina, et al.
Publicado: (2013)

Phenotypic Fingerprinting of Small Molecule Cell Cycle Kinase Inhibitors for Drug Discovery
por: Low, Jonathan, et al.
Publicado: (2009)

Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus
por: Demirci, Cem, et al.
Publicado: (2012)

Cytotoxicity against A549 Human Lung Cancer Cell Line via the Mitochondrial Membrane Potential and Nuclear Condensation Effects of Nepeta paulsenii Briq., a Perennial Herb
por: Hanif, Aqsa, et al.
Publicado: (2023)

Editorial: Non-cell Cycle Functions of Cell Cycle Regulators
por: Liu, Song-Tao, et al.
Publicado: (2019)

Hepatocyte Growth Factor/c-Met Signaling Is Required for β-Cell Regeneration
por: Alvarez-Perez, Juan Carlos, et al.
Publicado: (2014)

Transcriptional timing and noise of yeast cell cycle regulators—a single cell and single molecule approach
por: Amoussouvi, Aouefa, et al.
Publicado: (2018)

Small Molecule Kinase Inhibitors Provide Insight into Mps1 Cell Cycle Function
por: Kwiatkowski, Nicholas, et al.
Publicado: (2010)

Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices
por: Wei, Kathy Y., et al.
Publicado: (2015)

ERO1L promotes NSCLC development by modulating cell cycle‐related molecules
por: Shi, Xiujuan, et al.
Publicado: (2020)

Targeting Proliferation Signals and the Cell Cycle Machinery in Acute Leukemias: Novel Molecules on the Horizon
por: Ghelli Luserna di Rorà, Andrea, et al.
Publicado: (2023)

En Guard! The Interactions between Adenoviruses and the DNA Damage Response
por: Kleinberger, Tamar
Publicado: (2020)

Cilia and the cell cycle?
por: Quarmby, Lynne M., et al.
Publicado: (2005)

Adenovirus-mediated Genetic Removal of Signaling Molecules in Cultured Primary Mouse Embryonic Fibroblasts
por: Hawley, Steve P., et al.
Publicado: (2010)

Salmonella enterica serovar Typhimurium utilizes the ClpPX and Lon proteases for optimal fitness in the ceca of chickens
por: Troxell, Bryan
Publicado: (2016)

A type 6 secretion system (T6SS) encoded gene within Salmonella enterica serovar Enteritidis contributes to virulence
por: Troxell, Bryan
Publicado: (2018)

GSTM3 reverses the resistance of hepatoma cells to radiation by regulating the expression of cell cycle/apoptosis-related molecules
por: SUN, YING, et al.
Publicado: (2014)

Stromal interaction molecule 1 regulates growth, cell cycle, and apoptosis of human tongue squamous carcinoma cells
por: Cui, Xiaobo, et al.
Publicado: (2017)

Small Molecule Inhibitors of MERTK and FLT3 Induce Cell Cycle Arrest in Human CD8(+) T Cells
por: Powell, Richard M., et al.
Publicado: (2021)

Metal atom–guided conformational analysis of single polynuclear coordination molecules
por: Takada, Kenji, et al.
Publicado: (2021)

The Fluctuating Phenotype of the Lymphohematopoietic Stem Cell with Cell Cycle Transit
por: Habibian, Houri K., et al.
Publicado: (1998)

Small Molecule Supplements Improve Cultured Megakaryocyte Polyploidization by Modulating Multiple Cell Cycle Regulators
por: Zou, Xiaojing, et al.
Publicado: (2017)

Protein synthesis molecule by molecule
por: Golding, Ido, et al.
Publicado: (2006)

Upregulation of nAChRs and Changes in Excitability on VTA Dopamine and GABA Neurons Correlates to Changes in Nicotine-Reward-Related Behavior
por: Akers, Austin T., et al.
Publicado: (2020)

SLAM-SAP-Fyn: Old Players with New Roles in iNKT Cell Development and Function
por: Bahal, Devika, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0kh06mjebpjpff02dblc8c4558