Hyperglycemia-Induced Protein Kinase C β(2) Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling

Protein kinase C (PKC)β(2) is preferably overexpressed in the diabetic myocardium, which induces cardiomyocyte hypertrophy and contributes to diabetic cardiomyopathy, but the underlying mechanisms are incompletely understood. Caveolae are critical in signal transduction of PKC isoforms in cardiomyoc...

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Detalles Bibliográficos
Autores principales: Lei, Shaoqing, Li, Haobo, Xu, Jinjin, Liu, Yanan, Gao, Xia, Wang, Junwen, Ng, Kwok F.J., Lau, Wayne Bond, Ma, Xin-liang, Rodrigues, Brian, Irwin, Michael G., Xia, Zhengyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712061/
https://www.ncbi.nlm.nih.gov/pubmed/23474486
http://dx.doi.org/10.2337/db12-1391

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