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Moderate GLUT4 Overexpression Improves Insulin Sensitivity and Fasting Triglyceridemia in High-Fat Diet–Fed Transgenic Mice
The GLUT4 facilitative glucose transporter mediates insulin-dependent glucose uptake. We tested the hypothesis that moderate overexpression of human GLUT4 in mice, under the regulation of the human GLUT4 promoter, can prevent the hyperinsulinemia that results from obesity. Transgenic mice engineered...
Autores principales: | Atkinson, Brittanie J., Griesel, Beth A., King, Caleb D., Josey, Miranda A., Olson, Ann Louise |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712063/ https://www.ncbi.nlm.nih.gov/pubmed/23474483 http://dx.doi.org/10.2337/db12-1146 |
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