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Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency
Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released from the gut in response to nutrient ingestion and that has a range of metabolic effects, including enhancing insulin secretion and decreasing food intake. Postprandial GLP-1 secretion is greatly enhanced in rats and humans after...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712071/ https://www.ncbi.nlm.nih.gov/pubmed/23434938 http://dx.doi.org/10.2337/db12-1498 |
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author | Wilson-Pérez, Hilary E. Chambers, Adam P. Ryan, Karen K. Li, Bailing Sandoval, Darleen A. Stoffers, Doris Drucker, Daniel J. Pérez-Tilve, Diego Seeley, Randy J. |
author_facet | Wilson-Pérez, Hilary E. Chambers, Adam P. Ryan, Karen K. Li, Bailing Sandoval, Darleen A. Stoffers, Doris Drucker, Daniel J. Pérez-Tilve, Diego Seeley, Randy J. |
author_sort | Wilson-Pérez, Hilary E. |
collection | PubMed |
description | Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released from the gut in response to nutrient ingestion and that has a range of metabolic effects, including enhancing insulin secretion and decreasing food intake. Postprandial GLP-1 secretion is greatly enhanced in rats and humans after some bariatric procedures, including vertical sleeve gastrectomy (VSG), and has been widely hypothesized to contribute to reduced intake, weight loss, and the improvements in glucose homeostasis after VSG. We tested this hypothesis using two separate models of GLP-1 receptor deficiency. We found that VSG-operated GLP-1 receptor–deficient mice responded similarly to wild-type controls in terms of body weight and body fat loss, improved glucose tolerance, food intake reduction, and altered food selection. These data demonstrate that GLP-1 receptor activity is not necessary for the metabolic improvements induced by VSG surgery. |
format | Online Article Text |
id | pubmed-3712071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-37120712014-07-01 Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency Wilson-Pérez, Hilary E. Chambers, Adam P. Ryan, Karen K. Li, Bailing Sandoval, Darleen A. Stoffers, Doris Drucker, Daniel J. Pérez-Tilve, Diego Seeley, Randy J. Diabetes Original Research Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released from the gut in response to nutrient ingestion and that has a range of metabolic effects, including enhancing insulin secretion and decreasing food intake. Postprandial GLP-1 secretion is greatly enhanced in rats and humans after some bariatric procedures, including vertical sleeve gastrectomy (VSG), and has been widely hypothesized to contribute to reduced intake, weight loss, and the improvements in glucose homeostasis after VSG. We tested this hypothesis using two separate models of GLP-1 receptor deficiency. We found that VSG-operated GLP-1 receptor–deficient mice responded similarly to wild-type controls in terms of body weight and body fat loss, improved glucose tolerance, food intake reduction, and altered food selection. These data demonstrate that GLP-1 receptor activity is not necessary for the metabolic improvements induced by VSG surgery. American Diabetes Association 2013-07 2013-06-14 /pmc/articles/PMC3712071/ /pubmed/23434938 http://dx.doi.org/10.2337/db12-1498 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Wilson-Pérez, Hilary E. Chambers, Adam P. Ryan, Karen K. Li, Bailing Sandoval, Darleen A. Stoffers, Doris Drucker, Daniel J. Pérez-Tilve, Diego Seeley, Randy J. Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency |
title | Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency |
title_full | Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency |
title_fullStr | Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency |
title_full_unstemmed | Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency |
title_short | Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency |
title_sort | vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like peptide 1 receptor deficiency |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712071/ https://www.ncbi.nlm.nih.gov/pubmed/23434938 http://dx.doi.org/10.2337/db12-1498 |
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