Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells

Conversion of one terminally differentiated cell type into another (or transdifferentiation) usually requires the forced expression of key transcription factors. We examined the plasticity of human insulin-producing β-cells in a model of islet cell aggregate formation. Here, we show that primary hum...

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Detalles Bibliográficos
Autores principales: Spijker, H. Siebe, Ravelli, Raimond B.G., Mommaas-Kienhuis, A. Mieke, van Apeldoorn, Aart A., Engelse, Marten A., Zaldumbide, Arnaud, Bonner-Weir, Susan, Rabelink, Ton J., Hoeben, Rob C., Clevers, Hans, Mummery, Christine L., Carlotti, Françoise, de Koning, Eelco J.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712074/
https://www.ncbi.nlm.nih.gov/pubmed/23569174
http://dx.doi.org/10.2337/db12-1001

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