Mutascope: sensitive detection of somatic mutations from deep amplicon sequencing

Summary: We present Mutascope, a sequencing analysis pipeline specifically developed for the identification of somatic variants present at low-allelic fraction from high-throughput sequencing of amplicons from matched tumor-normal specimen. Using datasets reproducing tumor genetic heterogeneity, we...

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Detalles Bibliográficos
Autores principales: Yost, Shawn E., Alakus, Hakan, Matsui, Hiroko, Schwab, Richard B., Jepsen, Kristen, Frazer, Kelly A., Harismendy, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712217/
https://www.ncbi.nlm.nih.gov/pubmed/23712659
http://dx.doi.org/10.1093/bioinformatics/btt305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712217/
https://www.ncbi.nlm.nih.gov/pubmed/23712659
http://dx.doi.org/10.1093/bioinformatics/btt305

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