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Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense

Over recent years it has become increasingly apparent that mucosal antibodies are not only restricted to the IgM and IgA isotypes, but that also other isotypes and particularly IgG can be found in significant quantities at some mucosal surfaces, such as in the genital tract. Their role is more compl...

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Detalles Bibliográficos
Autores principales: Horton, Rachel E., Vidarsson, Gestur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712224/
https://www.ncbi.nlm.nih.gov/pubmed/23882268
http://dx.doi.org/10.3389/fimmu.2013.00200
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author Horton, Rachel E.
Vidarsson, Gestur
author_facet Horton, Rachel E.
Vidarsson, Gestur
author_sort Horton, Rachel E.
collection PubMed
description Over recent years it has become increasingly apparent that mucosal antibodies are not only restricted to the IgM and IgA isotypes, but that also other isotypes and particularly IgG can be found in significant quantities at some mucosal surfaces, such as in the genital tract. Their role is more complex than traditionally believed with, among other things, the discovery of novel function of mucosal immunoglobulin receptors. A thorough knowledge in the source and function and mucosal immunoglobulins is particularly important in development of vaccines providing mucosal immunity, and also in the current climate of microbicide development, to combat major world health issues such as HIV. We present here a comprehensive review of human antibody mediated mucosal immunity.
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spelling pubmed-37122242013-07-23 Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense Horton, Rachel E. Vidarsson, Gestur Front Immunol Immunology Over recent years it has become increasingly apparent that mucosal antibodies are not only restricted to the IgM and IgA isotypes, but that also other isotypes and particularly IgG can be found in significant quantities at some mucosal surfaces, such as in the genital tract. Their role is more complex than traditionally believed with, among other things, the discovery of novel function of mucosal immunoglobulin receptors. A thorough knowledge in the source and function and mucosal immunoglobulins is particularly important in development of vaccines providing mucosal immunity, and also in the current climate of microbicide development, to combat major world health issues such as HIV. We present here a comprehensive review of human antibody mediated mucosal immunity. Frontiers Media S.A. 2013-07-16 /pmc/articles/PMC3712224/ /pubmed/23882268 http://dx.doi.org/10.3389/fimmu.2013.00200 Text en Copyright © 2013 Horton and Vidarsson. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Horton, Rachel E.
Vidarsson, Gestur
Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense
title Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense
title_full Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense
title_fullStr Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense
title_full_unstemmed Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense
title_short Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense
title_sort antibodies and their receptors: different potential roles in mucosal defense
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712224/
https://www.ncbi.nlm.nih.gov/pubmed/23882268
http://dx.doi.org/10.3389/fimmu.2013.00200
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