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Conformational switching of the 26S proteasome enables substrate degradation

The 26S proteasome is the major eukaryotic ATP-dependent protease, responsible for regulating the proteome through degradation of ubiquitin-tagged substrates. Its regulatory particle, containing the heterohexameric AAA+ ATPase motor and the essential deubiquitinase Rpn11, recognizes substrates, remo...

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Detalles Bibliográficos
Autores principales:	Matyskiela, Mary E., Lander, Gabriel C., Martin, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712289/ https://www.ncbi.nlm.nih.gov/pubmed/23770819 http://dx.doi.org/10.1038/nsmb.2616

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