Cargando…

Prenatal treatment of mothers with fetuses at risk for congenital adrenal hyperplasia: How relevant is it to Indian context?

Management of congenital adrenal hyperplasia (CAH) from embryonic stage to adulthood is a critical challenge. We would like to comment on some of the practical difficulties in offering prenatal treatment for CAH-affected fetuses in Indian population. For initiating the prenatal dexamethasone (DEX) t...

Descripción completa

Detalles Bibliográficos
Autores principales: Eunice, Marumudi, Ammini, Ariachery C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712366/
https://www.ncbi.nlm.nih.gov/pubmed/23869292
http://dx.doi.org/10.4103/2230-8210.111596
_version_ 1782277060609179648
author Eunice, Marumudi
Ammini, Ariachery C.
author_facet Eunice, Marumudi
Ammini, Ariachery C.
author_sort Eunice, Marumudi
collection PubMed
description Management of congenital adrenal hyperplasia (CAH) from embryonic stage to adulthood is a critical challenge. We would like to comment on some of the practical difficulties in offering prenatal treatment for CAH-affected fetuses in Indian population. For initiating the prenatal dexamethasone (DEX) treatment, all members of the family need to be informed about the risks and benefits of the treatment to the mother and the fetus as well as about the available invasive diagnostic tests to determine the gender and genotype of the fetus. Prenatal sex disclosure is not routinely practiced in India due to high female feticide rate. The treatment has to be given to both unaffected and affected female fetuses until the determination of prenatal sex. Moreover, most of our populations reside in rural areas where the antenatal care is not adequate. Prenatal DEX treatment in India outruns the risks rather than the benefits, as evident from the literature on the safety of pregnant mothers and fetuses.
format Online
Article
Text
id pubmed-3712366
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-37123662013-07-18 Prenatal treatment of mothers with fetuses at risk for congenital adrenal hyperplasia: How relevant is it to Indian context? Eunice, Marumudi Ammini, Ariachery C. Indian J Endocrinol Metab Endocrinology and Gender Management of congenital adrenal hyperplasia (CAH) from embryonic stage to adulthood is a critical challenge. We would like to comment on some of the practical difficulties in offering prenatal treatment for CAH-affected fetuses in Indian population. For initiating the prenatal dexamethasone (DEX) treatment, all members of the family need to be informed about the risks and benefits of the treatment to the mother and the fetus as well as about the available invasive diagnostic tests to determine the gender and genotype of the fetus. Prenatal sex disclosure is not routinely practiced in India due to high female feticide rate. The treatment has to be given to both unaffected and affected female fetuses until the determination of prenatal sex. Moreover, most of our populations reside in rural areas where the antenatal care is not adequate. Prenatal DEX treatment in India outruns the risks rather than the benefits, as evident from the literature on the safety of pregnant mothers and fetuses. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3712366/ /pubmed/23869292 http://dx.doi.org/10.4103/2230-8210.111596 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Endocrinology and Gender
Eunice, Marumudi
Ammini, Ariachery C.
Prenatal treatment of mothers with fetuses at risk for congenital adrenal hyperplasia: How relevant is it to Indian context?
title Prenatal treatment of mothers with fetuses at risk for congenital adrenal hyperplasia: How relevant is it to Indian context?
title_full Prenatal treatment of mothers with fetuses at risk for congenital adrenal hyperplasia: How relevant is it to Indian context?
title_fullStr Prenatal treatment of mothers with fetuses at risk for congenital adrenal hyperplasia: How relevant is it to Indian context?
title_full_unstemmed Prenatal treatment of mothers with fetuses at risk for congenital adrenal hyperplasia: How relevant is it to Indian context?
title_short Prenatal treatment of mothers with fetuses at risk for congenital adrenal hyperplasia: How relevant is it to Indian context?
title_sort prenatal treatment of mothers with fetuses at risk for congenital adrenal hyperplasia: how relevant is it to indian context?
topic Endocrinology and Gender
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712366/
https://www.ncbi.nlm.nih.gov/pubmed/23869292
http://dx.doi.org/10.4103/2230-8210.111596
work_keys_str_mv AT eunicemarumudi prenataltreatmentofmotherswithfetusesatriskforcongenitaladrenalhyperplasiahowrelevantisittoindiancontext
AT amminiariacheryc prenataltreatmentofmotherswithfetusesatriskforcongenitaladrenalhyperplasiahowrelevantisittoindiancontext