Persistence of histoplasma in adrenals 7 years after antifungal therapy

Adrenal histoplasmosis is an uncommon cause for adrenal insufficiency. The duration of treatment for adrenal histoplasmosis is not clear. Existing treatment regimens advocate antifungals given for periods ranging from 6 months to 2 years. We report here a rare case who showed persistence of histopla...

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Detalles Bibliográficos
Autores principales: Kothari, Deepak, Chopra, Shweta, Bhardwaj, Minakshi, Ajmani, Ajay K., Kulshreshtha, Bindu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712391/
https://www.ncbi.nlm.nih.gov/pubmed/23869317
http://dx.doi.org/10.4103/2230-8210.111679
Descripción
Sumario:Adrenal histoplasmosis is an uncommon cause for adrenal insufficiency. The duration of treatment for adrenal histoplasmosis is not clear. Existing treatment regimens advocate antifungals given for periods ranging from 6 months to 2 years. We report here a rare case who showed persistence of histoplasma in adrenal biopsy 7 years after being initially treated with itraconazole for 9 months. This calls for a prolonged therapy with regular review of adrenal morphology and histology in these patients.

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