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CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome

AIMS: To investigate the aberrant expression of CD117 in oesophageal squamous cell carcinoma (SCC) and its prognostic significance. METHODS AND RESULTS: Immunohistochemical staining for CD117 was performed on tissue microarray and routine tissue sections from 157 oesophageal SCC patients and 10 norm...

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Autores principales: Fan, Huijie, Yuan, Yuan, Wang, Junsheng, Zhou, Fuyou, Zhang, Mingzhi, Giercksky, Karl-Erik, Nesland, Jahn M, Suo, Zhenhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712472/
https://www.ncbi.nlm.nih.gov/pubmed/23570416
http://dx.doi.org/10.1111/his.12111
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author Fan, Huijie
Yuan, Yuan
Wang, Junsheng
Zhou, Fuyou
Zhang, Mingzhi
Giercksky, Karl-Erik
Nesland, Jahn M
Suo, Zhenhe
author_facet Fan, Huijie
Yuan, Yuan
Wang, Junsheng
Zhou, Fuyou
Zhang, Mingzhi
Giercksky, Karl-Erik
Nesland, Jahn M
Suo, Zhenhe
author_sort Fan, Huijie
collection PubMed
description AIMS: To investigate the aberrant expression of CD117 in oesophageal squamous cell carcinoma (SCC) and its prognostic significance. METHODS AND RESULTS: Immunohistochemical staining for CD117 was performed on tissue microarray and routine tissue sections from 157 oesophageal SCC patients and 10 normal oesophageal epithelia adjacent to tumour. The positive rate of CD117 expression was 29.9% in oesophageal SCC tissues, whereas no CD117 expression was detected in the 10 normal oesophageal epithelia. CD117 expression was significantly associated with T stage (P < 0.001), distant metastasis (P = 0.015), lymph node metastasis (P = 0.019), and clinical stage (P = 0.021). Progression-free survival in the patients with CD117-positive tumours was shorter than that in the patients with CD117-negative tumours (P = 0.010). In univariate analyses, CD117 expression was the most significant factor for overall survival of oesophageal SCC patients (P < 0.001), followed by lymph node metastasis (P = 0.001), T stage (P = 0.002), clinical stage (P = 0.006), distant metastasis (P = 0.020), and histological grade (P = 0.027). Multivariate analyses verified that CD117 expression was an independent prognostic marker for oesophageal SCC patients (P = 0.002). In addition, CD117 expression predicted poorer survival in patients without distant metastases. CONCLUSIONS: CD117 expression in operable oesophageal SCC may be a valuable prognostic marker, and detection of its expression in clinical samples may be useful in defining a subclass of oesophageal SCCs with extremely poor clinical outcome, which may require a specially targeted treatment modality.
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spelling pubmed-37124722013-07-25 CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome Fan, Huijie Yuan, Yuan Wang, Junsheng Zhou, Fuyou Zhang, Mingzhi Giercksky, Karl-Erik Nesland, Jahn M Suo, Zhenhe Histopathology Original Articles AIMS: To investigate the aberrant expression of CD117 in oesophageal squamous cell carcinoma (SCC) and its prognostic significance. METHODS AND RESULTS: Immunohistochemical staining for CD117 was performed on tissue microarray and routine tissue sections from 157 oesophageal SCC patients and 10 normal oesophageal epithelia adjacent to tumour. The positive rate of CD117 expression was 29.9% in oesophageal SCC tissues, whereas no CD117 expression was detected in the 10 normal oesophageal epithelia. CD117 expression was significantly associated with T stage (P < 0.001), distant metastasis (P = 0.015), lymph node metastasis (P = 0.019), and clinical stage (P = 0.021). Progression-free survival in the patients with CD117-positive tumours was shorter than that in the patients with CD117-negative tumours (P = 0.010). In univariate analyses, CD117 expression was the most significant factor for overall survival of oesophageal SCC patients (P < 0.001), followed by lymph node metastasis (P = 0.001), T stage (P = 0.002), clinical stage (P = 0.006), distant metastasis (P = 0.020), and histological grade (P = 0.027). Multivariate analyses verified that CD117 expression was an independent prognostic marker for oesophageal SCC patients (P = 0.002). In addition, CD117 expression predicted poorer survival in patients without distant metastases. CONCLUSIONS: CD117 expression in operable oesophageal SCC may be a valuable prognostic marker, and detection of its expression in clinical samples may be useful in defining a subclass of oesophageal SCCs with extremely poor clinical outcome, which may require a specially targeted treatment modality. Blackwell Publishing Ltd 2013-06 2013-02-11 /pmc/articles/PMC3712472/ /pubmed/23570416 http://dx.doi.org/10.1111/his.12111 Text en Copyright © 2013 John Wiley & Sons Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Original Articles
Fan, Huijie
Yuan, Yuan
Wang, Junsheng
Zhou, Fuyou
Zhang, Mingzhi
Giercksky, Karl-Erik
Nesland, Jahn M
Suo, Zhenhe
CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome
title CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome
title_full CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome
title_fullStr CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome
title_full_unstemmed CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome
title_short CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome
title_sort cd117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712472/
https://www.ncbi.nlm.nih.gov/pubmed/23570416
http://dx.doi.org/10.1111/his.12111
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