Efemp1 and p27(Kip1) modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models

Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease with a poor prognosis and targeted therapies have failed in the clinic so far. Several evidences point to the phosphatidylinositol 3-kinase (PI3K)-mTOR pathway as a promising signaling node for targeted therapeutic intervention. Marker...

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Detalles Bibliográficos
Autores principales: Diersch, Sandra, Patrick, Wenzel, Szameitat, Melanie, Eser, Philipp, Paul, Mariel C., Seidler, Barbara, Eser, Stefan, Messer, Marlena, Reichert, Maximilian, Pagel, Philipp, Esposito, Irene, Schmid, Roland M., Saur, Dieter, Schneider, Günter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712573/
https://www.ncbi.nlm.nih.gov/pubmed/23470560

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