Passenger Deletions Generate Therapeutic Vulnerabilities in Cancer

Inactivation of tumor suppressor genes via homozygous deletion is a prototypic event in the cancer genome, yet such deletions often encompass neighboring genes. We hypothesized that homozygous deletions in such passenger genes can expose cancer-specific therapeutic vulnerabilities in the case where...

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Detalles Bibliográficos
Autores principales: Muller, Florian L., Colla, Simona, Aquilanti, Elisa, Manzo, Veronica, Genovese, Giannicola, Lee, Jaclyn, Eisenson, Dan, Narurkar, Rujuta, Deng, Pingna, Nezi, Luigi, Lee, Michelle, Hu, Baoli, Hu, Jian, Sahin, Ergun, Ong, Derrick, Fletcher-Sananikone, Eliot, Ho, Dennis, Kwong, Lawrence, Brennan, Cameron, Wang, Y. Alan, Chin, Lynda, DePinho, Ronald A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712624/
https://www.ncbi.nlm.nih.gov/pubmed/22895339
http://dx.doi.org/10.1038/nature11331

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