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Remodeling of Tumor Stroma and Response to Therapy

Solid tumors are intrinsically resistant to therapy. Cancer progression occurs when tumor cells orchestrate responses from diverse stromal cell types such as blood vessels and their support cells, inflammatory cells, and fibroblasts; these cells collectively form the tumor microenvironment and provi...

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Detalles Bibliográficos
Autores principales: Johansson, Anna, Ganss, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712692/
https://www.ncbi.nlm.nih.gov/pubmed/24213314
http://dx.doi.org/10.3390/cancers4020340
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author Johansson, Anna
Ganss, Ruth
author_facet Johansson, Anna
Ganss, Ruth
author_sort Johansson, Anna
collection PubMed
description Solid tumors are intrinsically resistant to therapy. Cancer progression occurs when tumor cells orchestrate responses from diverse stromal cell types such as blood vessels and their support cells, inflammatory cells, and fibroblasts; these cells collectively form the tumor microenvironment and provide direct support for tumor growth, but also evasion from cytotoxic, immune and radiation therapies. An indirect result of abnormal and leaky blood vessels in solid tumors is high interstitial fluid pressure, which reduces drug penetration, but also creates a hypoxic environment that further augments tumor cell growth and metastatic spread. Importantly however, studies during the last decade have shown that the tumor stroma, including the vasculature, can be modulated, or re-educated, to allow better delivery of chemotherapeutic drugs or enhance the efficiency of active immune therapy. Such remodeling of the tumor stroma using genetic, pharmacological and other therapeutic approaches not only enhances selective access into tumors but also reduces toxic side effects. This review focuses on recent novel concepts to modulate tumor stroma and thus locally increase therapeutic efficacy.
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spelling pubmed-37126922013-08-05 Remodeling of Tumor Stroma and Response to Therapy Johansson, Anna Ganss, Ruth Cancers (Basel) Review Solid tumors are intrinsically resistant to therapy. Cancer progression occurs when tumor cells orchestrate responses from diverse stromal cell types such as blood vessels and their support cells, inflammatory cells, and fibroblasts; these cells collectively form the tumor microenvironment and provide direct support for tumor growth, but also evasion from cytotoxic, immune and radiation therapies. An indirect result of abnormal and leaky blood vessels in solid tumors is high interstitial fluid pressure, which reduces drug penetration, but also creates a hypoxic environment that further augments tumor cell growth and metastatic spread. Importantly however, studies during the last decade have shown that the tumor stroma, including the vasculature, can be modulated, or re-educated, to allow better delivery of chemotherapeutic drugs or enhance the efficiency of active immune therapy. Such remodeling of the tumor stroma using genetic, pharmacological and other therapeutic approaches not only enhances selective access into tumors but also reduces toxic side effects. This review focuses on recent novel concepts to modulate tumor stroma and thus locally increase therapeutic efficacy. MDPI 2012-03-27 /pmc/articles/PMC3712692/ /pubmed/24213314 http://dx.doi.org/10.3390/cancers4020340 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Johansson, Anna
Ganss, Ruth
Remodeling of Tumor Stroma and Response to Therapy
title Remodeling of Tumor Stroma and Response to Therapy
title_full Remodeling of Tumor Stroma and Response to Therapy
title_fullStr Remodeling of Tumor Stroma and Response to Therapy
title_full_unstemmed Remodeling of Tumor Stroma and Response to Therapy
title_short Remodeling of Tumor Stroma and Response to Therapy
title_sort remodeling of tumor stroma and response to therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712692/
https://www.ncbi.nlm.nih.gov/pubmed/24213314
http://dx.doi.org/10.3390/cancers4020340
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