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Investigation The Role of Gender on The HLA-DRB1 and -DQB1 Association with Type 1 Diabetes Mellitus in Iranian Patients
OBJECTIVE: Type 1 diabetes mellitus (T1D) is an autoimmune and multifactorial disorder. Subsequent analysis on human leukocyte antigen ( HLA) region shows that HLA-DRB1 and -DQB1 genes have the strongest association with T1D. In this study, for the first time, we investigated the influence of gender...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712770/ https://www.ncbi.nlm.nih.gov/pubmed/23862111 |
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author | Sayad, Arezou Akbari, Mohammad Taghi Pajouhi, Mohammad Mostafavi, Feridoon Kazemnejad, Anooshirvan Zamani, Mahdi |
author_facet | Sayad, Arezou Akbari, Mohammad Taghi Pajouhi, Mohammad Mostafavi, Feridoon Kazemnejad, Anooshirvan Zamani, Mahdi |
author_sort | Sayad, Arezou |
collection | PubMed |
description | OBJECTIVE: Type 1 diabetes mellitus (T1D) is an autoimmune and multifactorial disorder. Subsequent analysis on human leukocyte antigen ( HLA) region shows that HLA-DRB1 and -DQB1 genes have the strongest association with T1D. In this study, for the first time, we investigated the influence of gender on the HLA-DRB1 and -DQB1 association with type 1 diabetes mellitus in Iranian patients in order to determine gender dependent HLA heterogeneity in Iranian T1D patients. MATERIALS AND METHODS: In this case control study, the HLA-DRB1 and -DQB1 typing were performed on 105 Iranian T1D patients and 100 healthy controls. The data were evaluated by using Fisher exact test. RESULTS: Our results indicate that DRB1*04:01, DQB1*03:02 alleles and DRB1*04:01- DQB1*03:02 haplotype were significantly more frequent in male T1D patients than females. Also, DRB1*03:01, DRB1*15:01, DQB1*06:01 alleles, DQB1*03:01/05:01 genotype, DRB1*03:01-DQB1*02:01 and DRB1*15:01-DQB1*06:01 haplotypes were significantly higher in female T1D group than males. Furthermore, our results showed that DRB1*04:01 and DQB1*03:02 alleles were significantly more frequent in male T1D patients 1-5 years old at onset than females with similar condition. The DRB1*03:01 allele and DRB1*03:01- DQB1*02:01 haplotype were significantly higher in female T1D patients 6-10 years old at onset than males with similar condition. The DRB1*15:01 allele and DRB1*15:01-DQB1*06:01 haplotype were significantly more frequent in female T1D patients 16-20 years old at onset than males with similar condition. CONCLUSION: Our findings suggest that gender has a significant influence on the distribution of HLA-DR and -DQ alleles, genotypes and haplotypes. Also, distribution of the HLA-DRB1 and -DQB1 alleles, genotypes and haplotypes vary based on the gender of T1D patients in different age at onset. |
format | Online Article Text |
id | pubmed-3712770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-37127702013-07-16 Investigation The Role of Gender on The HLA-DRB1 and -DQB1 Association with Type 1 Diabetes Mellitus in Iranian Patients Sayad, Arezou Akbari, Mohammad Taghi Pajouhi, Mohammad Mostafavi, Feridoon Kazemnejad, Anooshirvan Zamani, Mahdi Cell J Research Article OBJECTIVE: Type 1 diabetes mellitus (T1D) is an autoimmune and multifactorial disorder. Subsequent analysis on human leukocyte antigen ( HLA) region shows that HLA-DRB1 and -DQB1 genes have the strongest association with T1D. In this study, for the first time, we investigated the influence of gender on the HLA-DRB1 and -DQB1 association with type 1 diabetes mellitus in Iranian patients in order to determine gender dependent HLA heterogeneity in Iranian T1D patients. MATERIALS AND METHODS: In this case control study, the HLA-DRB1 and -DQB1 typing were performed on 105 Iranian T1D patients and 100 healthy controls. The data were evaluated by using Fisher exact test. RESULTS: Our results indicate that DRB1*04:01, DQB1*03:02 alleles and DRB1*04:01- DQB1*03:02 haplotype were significantly more frequent in male T1D patients than females. Also, DRB1*03:01, DRB1*15:01, DQB1*06:01 alleles, DQB1*03:01/05:01 genotype, DRB1*03:01-DQB1*02:01 and DRB1*15:01-DQB1*06:01 haplotypes were significantly higher in female T1D group than males. Furthermore, our results showed that DRB1*04:01 and DQB1*03:02 alleles were significantly more frequent in male T1D patients 1-5 years old at onset than females with similar condition. The DRB1*03:01 allele and DRB1*03:01- DQB1*02:01 haplotype were significantly higher in female T1D patients 6-10 years old at onset than males with similar condition. The DRB1*15:01 allele and DRB1*15:01-DQB1*06:01 haplotype were significantly more frequent in female T1D patients 16-20 years old at onset than males with similar condition. CONCLUSION: Our findings suggest that gender has a significant influence on the distribution of HLA-DR and -DQ alleles, genotypes and haplotypes. Also, distribution of the HLA-DRB1 and -DQB1 alleles, genotypes and haplotypes vary based on the gender of T1D patients in different age at onset. Royan Institute 2013 2013-07-02 /pmc/articles/PMC3712770/ /pubmed/23862111 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sayad, Arezou Akbari, Mohammad Taghi Pajouhi, Mohammad Mostafavi, Feridoon Kazemnejad, Anooshirvan Zamani, Mahdi Investigation The Role of Gender on The HLA-DRB1 and -DQB1 Association with Type 1 Diabetes Mellitus in Iranian Patients |
title | Investigation The Role of Gender on The HLA-DRB1
and -DQB1 Association with Type 1 Diabetes Mellitus
in Iranian Patients |
title_full | Investigation The Role of Gender on The HLA-DRB1
and -DQB1 Association with Type 1 Diabetes Mellitus
in Iranian Patients |
title_fullStr | Investigation The Role of Gender on The HLA-DRB1
and -DQB1 Association with Type 1 Diabetes Mellitus
in Iranian Patients |
title_full_unstemmed | Investigation The Role of Gender on The HLA-DRB1
and -DQB1 Association with Type 1 Diabetes Mellitus
in Iranian Patients |
title_short | Investigation The Role of Gender on The HLA-DRB1
and -DQB1 Association with Type 1 Diabetes Mellitus
in Iranian Patients |
title_sort | investigation the role of gender on the hla-drb1
and -dqb1 association with type 1 diabetes mellitus
in iranian patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712770/ https://www.ncbi.nlm.nih.gov/pubmed/23862111 |
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