Sustained Remission of Antineutrophil Cytoplasmic Antibody-Mediated Glomerulonephritis and Nephrotic Syndrome in Mixed Connective Tissue Disease

A woman diagnosed with mixed connective tissue disease (MCTD) developed an anti-myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) and nephrotic syndrome with normal serum creatinine. Percutaneous kidney biopsy showed pauci-immune glomerulonephritis with superimposed immune complex dep...

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Autores principales: Konstantinov, Konstantin N., Harris, Alexis A., Barry, Marc, Murata, Glen H., Tzamaloukas, Antonios H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712889/
https://www.ncbi.nlm.nih.gov/pubmed/23864923
http://dx.doi.org/10.4021/jocmr1391w
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author Konstantinov, Konstantin N.
Harris, Alexis A.
Barry, Marc
Murata, Glen H.
Tzamaloukas, Antonios H.
author_facet Konstantinov, Konstantin N.
Harris, Alexis A.
Barry, Marc
Murata, Glen H.
Tzamaloukas, Antonios H.
author_sort Konstantinov, Konstantin N.
collection PubMed
description A woman diagnosed with mixed connective tissue disease (MCTD) developed an anti-myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) and nephrotic syndrome with normal serum creatinine. Percutaneous kidney biopsy showed pauci-immune glomerulonephritis with superimposed immune complex deposition. After treatment with cyclophophamide and prednisone, proteinuria decreased progressively to a level of 0.4 g/g creatinine, ANCA became undetectable, while serum creatinine remained normal seven years after the beginning of treatment. Sustained remission of nephrotic proteinuria with preserved renal function may follow treatment of ANCA-mediated disease developing in patients with MCTD.
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spelling pubmed-37128892013-07-17 Sustained Remission of Antineutrophil Cytoplasmic Antibody-Mediated Glomerulonephritis and Nephrotic Syndrome in Mixed Connective Tissue Disease Konstantinov, Konstantin N. Harris, Alexis A. Barry, Marc Murata, Glen H. Tzamaloukas, Antonios H. J Clin Med Res Case Report A woman diagnosed with mixed connective tissue disease (MCTD) developed an anti-myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) and nephrotic syndrome with normal serum creatinine. Percutaneous kidney biopsy showed pauci-immune glomerulonephritis with superimposed immune complex deposition. After treatment with cyclophophamide and prednisone, proteinuria decreased progressively to a level of 0.4 g/g creatinine, ANCA became undetectable, while serum creatinine remained normal seven years after the beginning of treatment. Sustained remission of nephrotic proteinuria with preserved renal function may follow treatment of ANCA-mediated disease developing in patients with MCTD. Elmer Press 2013-08 2013-06-21 /pmc/articles/PMC3712889/ /pubmed/23864923 http://dx.doi.org/10.4021/jocmr1391w Text en Copyright 2013, Konstantinov et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Konstantinov, Konstantin N.
Harris, Alexis A.
Barry, Marc
Murata, Glen H.
Tzamaloukas, Antonios H.
Sustained Remission of Antineutrophil Cytoplasmic Antibody-Mediated Glomerulonephritis and Nephrotic Syndrome in Mixed Connective Tissue Disease
title Sustained Remission of Antineutrophil Cytoplasmic Antibody-Mediated Glomerulonephritis and Nephrotic Syndrome in Mixed Connective Tissue Disease
title_full Sustained Remission of Antineutrophil Cytoplasmic Antibody-Mediated Glomerulonephritis and Nephrotic Syndrome in Mixed Connective Tissue Disease
title_fullStr Sustained Remission of Antineutrophil Cytoplasmic Antibody-Mediated Glomerulonephritis and Nephrotic Syndrome in Mixed Connective Tissue Disease
title_full_unstemmed Sustained Remission of Antineutrophil Cytoplasmic Antibody-Mediated Glomerulonephritis and Nephrotic Syndrome in Mixed Connective Tissue Disease
title_short Sustained Remission of Antineutrophil Cytoplasmic Antibody-Mediated Glomerulonephritis and Nephrotic Syndrome in Mixed Connective Tissue Disease
title_sort sustained remission of antineutrophil cytoplasmic antibody-mediated glomerulonephritis and nephrotic syndrome in mixed connective tissue disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712889/
https://www.ncbi.nlm.nih.gov/pubmed/23864923
http://dx.doi.org/10.4021/jocmr1391w
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