Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly

To find histone deacetylase 3 (HDAC3)-selective inhibitors, a series of 504 candidates was assembled using “click chemistry”, by reacting nine alkynes bearing a zinc-binding group with 56 azide building blocks in the presence of Cu(I) catalyst. Screening of the 504-member triazole library against HD...

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Detalles Bibliográficos
Autores principales: Suzuki, Takayoshi, Kasuya, Yuki, Itoh, Yukihiro, Ota, Yosuke, Zhan, Peng, Asamitsu, Kaori, Nakagawa, Hidehiko, Okamoto, Takashi, Miyata, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713009/
https://www.ncbi.nlm.nih.gov/pubmed/23874714
http://dx.doi.org/10.1371/journal.pone.0068669

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