Cargando…

Integrative genomic analysis of the human immune response to influenza vaccination

Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza...

Descripción completa

Detalles Bibliográficos
Autores principales: Franco, Luis M, Bucasas, Kristine L, Wells, Janet M, Niño, Diane, Wang, Xueqing, Zapata, Gladys E, Arden, Nancy, Renwick, Alexander, Yu, Peng, Quarles, John M, Bray, Molly S, Couch, Robert B, Belmont, John W, Shaw, Chad A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713456/
https://www.ncbi.nlm.nih.gov/pubmed/23878721
http://dx.doi.org/10.7554/eLife.00299
Descripción
Sumario:Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits. DOI: http://dx.doi.org/10.7554/eLife.00299.001