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Integrative genomic analysis of the human immune response to influenza vaccination
Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713456/ https://www.ncbi.nlm.nih.gov/pubmed/23878721 http://dx.doi.org/10.7554/eLife.00299 |
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author | Franco, Luis M Bucasas, Kristine L Wells, Janet M Niño, Diane Wang, Xueqing Zapata, Gladys E Arden, Nancy Renwick, Alexander Yu, Peng Quarles, John M Bray, Molly S Couch, Robert B Belmont, John W Shaw, Chad A |
author_facet | Franco, Luis M Bucasas, Kristine L Wells, Janet M Niño, Diane Wang, Xueqing Zapata, Gladys E Arden, Nancy Renwick, Alexander Yu, Peng Quarles, John M Bray, Molly S Couch, Robert B Belmont, John W Shaw, Chad A |
author_sort | Franco, Luis M |
collection | PubMed |
description | Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits. DOI: http://dx.doi.org/10.7554/eLife.00299.001 |
format | Online Article Text |
id | pubmed-3713456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37134562013-07-22 Integrative genomic analysis of the human immune response to influenza vaccination Franco, Luis M Bucasas, Kristine L Wells, Janet M Niño, Diane Wang, Xueqing Zapata, Gladys E Arden, Nancy Renwick, Alexander Yu, Peng Quarles, John M Bray, Molly S Couch, Robert B Belmont, John W Shaw, Chad A eLife Human Biology and Medicine Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits. DOI: http://dx.doi.org/10.7554/eLife.00299.001 eLife Sciences Publications, Ltd 2013-07-16 /pmc/articles/PMC3713456/ /pubmed/23878721 http://dx.doi.org/10.7554/eLife.00299 Text en © 2013, Franco et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Human Biology and Medicine Franco, Luis M Bucasas, Kristine L Wells, Janet M Niño, Diane Wang, Xueqing Zapata, Gladys E Arden, Nancy Renwick, Alexander Yu, Peng Quarles, John M Bray, Molly S Couch, Robert B Belmont, John W Shaw, Chad A Integrative genomic analysis of the human immune response to influenza vaccination |
title | Integrative genomic analysis of the human immune response to influenza vaccination |
title_full | Integrative genomic analysis of the human immune response to influenza vaccination |
title_fullStr | Integrative genomic analysis of the human immune response to influenza vaccination |
title_full_unstemmed | Integrative genomic analysis of the human immune response to influenza vaccination |
title_short | Integrative genomic analysis of the human immune response to influenza vaccination |
title_sort | integrative genomic analysis of the human immune response to influenza vaccination |
topic | Human Biology and Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713456/ https://www.ncbi.nlm.nih.gov/pubmed/23878721 http://dx.doi.org/10.7554/eLife.00299 |
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