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Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout

Background: Hyperuricemia is known to be a risk factor for incident type 2 diabetes mellitus, but the absolute magnitude of the association is not known. We aimed to evaluate the strength of association between hyperuricemia and the risk of developing diabetes among the US veterans with gout. Method...

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Autores principales: Krishnan, E., Akhras, K.S., Sharma, H., Marynchenko, M., Wu, E.Q., Tawk, R., Liu, J., Shi, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713590/
https://www.ncbi.nlm.nih.gov/pubmed/23620537
http://dx.doi.org/10.1093/qjmed/hct093
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author Krishnan, E.
Akhras, K.S.
Sharma, H.
Marynchenko, M.
Wu, E.Q.
Tawk, R.
Liu, J.
Shi, L.
author_facet Krishnan, E.
Akhras, K.S.
Sharma, H.
Marynchenko, M.
Wu, E.Q.
Tawk, R.
Liu, J.
Shi, L.
author_sort Krishnan, E.
collection PubMed
description Background: Hyperuricemia is known to be a risk factor for incident type 2 diabetes mellitus, but the absolute magnitude of the association is not known. We aimed to evaluate the strength of association between hyperuricemia and the risk of developing diabetes among the US veterans with gout. Methods: Patients (age ≥ 18 years) with ≥2 clinical encounters with gout diagnoses, no history of inflammatory diseases or diabetes and two serum urate (sUA) measurements between 1 January 2002 and 1 January 2011 were selected. Diabetes was identified using International Classification of Disease-9-Clinical Modification codes, use of anti-diabetic medications or HbA1c ≥6.5%. sUA levels were assessed at 6-month cycles (hyperuricemia: sUA >7 mg/dl). Accumulated hazard curves for time to first diabetes diagnosis were derived from Kaplan–Meier (KM) analysis. Risk of diabetes associated with hyperuricemia was estimated using a Cox proportional hazards model. Population attributable fraction (AF) of new-onset diabetes within 1 year was estimated using logistic regression. Results: Among 1923 patients, average age was 62.9 years, body mass index was 30.6 kg/m(2), and follow-up time was 80 months. Diabetes rates from KM were 19% for sUA ≤ 7 mg/dl, 23% for 7 mg/dl < sUA ≤ 9 mg/dl and 27% for sUA > 9 mg/dl at the end of follow-up period (P < 0.001). Hyperuricemia was associated with a significantly higher risk of developing diabetes, after adjusting for confounding factors (hazard ratio: 1.19, 95% confidence interval: [1.01–1.41]). Approximately, 8.7% of all new cases of diabetes were statistically attributed to hyperuricemia. Conclusions: Among veterans, hyperuricemia was associated with excess risk for developing diabetes. Approximately, 1 in 11 new cases of diabetes were statistically attributed to hyperuricemia.
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spelling pubmed-37135902013-07-17 Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout Krishnan, E. Akhras, K.S. Sharma, H. Marynchenko, M. Wu, E.Q. Tawk, R. Liu, J. Shi, L. QJM Original Papers Background: Hyperuricemia is known to be a risk factor for incident type 2 diabetes mellitus, but the absolute magnitude of the association is not known. We aimed to evaluate the strength of association between hyperuricemia and the risk of developing diabetes among the US veterans with gout. Methods: Patients (age ≥ 18 years) with ≥2 clinical encounters with gout diagnoses, no history of inflammatory diseases or diabetes and two serum urate (sUA) measurements between 1 January 2002 and 1 January 2011 were selected. Diabetes was identified using International Classification of Disease-9-Clinical Modification codes, use of anti-diabetic medications or HbA1c ≥6.5%. sUA levels were assessed at 6-month cycles (hyperuricemia: sUA >7 mg/dl). Accumulated hazard curves for time to first diabetes diagnosis were derived from Kaplan–Meier (KM) analysis. Risk of diabetes associated with hyperuricemia was estimated using a Cox proportional hazards model. Population attributable fraction (AF) of new-onset diabetes within 1 year was estimated using logistic regression. Results: Among 1923 patients, average age was 62.9 years, body mass index was 30.6 kg/m(2), and follow-up time was 80 months. Diabetes rates from KM were 19% for sUA ≤ 7 mg/dl, 23% for 7 mg/dl < sUA ≤ 9 mg/dl and 27% for sUA > 9 mg/dl at the end of follow-up period (P < 0.001). Hyperuricemia was associated with a significantly higher risk of developing diabetes, after adjusting for confounding factors (hazard ratio: 1.19, 95% confidence interval: [1.01–1.41]). Approximately, 8.7% of all new cases of diabetes were statistically attributed to hyperuricemia. Conclusions: Among veterans, hyperuricemia was associated with excess risk for developing diabetes. Approximately, 1 in 11 new cases of diabetes were statistically attributed to hyperuricemia. Oxford University Press 2013-08 2013-04-24 /pmc/articles/PMC3713590/ /pubmed/23620537 http://dx.doi.org/10.1093/qjmed/hct093 Text en © The Author(s) 2013. Published by Oxford University Press on behalf of the Association of Physicians. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Papers
Krishnan, E.
Akhras, K.S.
Sharma, H.
Marynchenko, M.
Wu, E.Q.
Tawk, R.
Liu, J.
Shi, L.
Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout
title Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout
title_full Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout
title_fullStr Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout
title_full_unstemmed Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout
title_short Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout
title_sort relative and attributable diabetes risk associated with hyperuricemia in us veterans with gout
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713590/
https://www.ncbi.nlm.nih.gov/pubmed/23620537
http://dx.doi.org/10.1093/qjmed/hct093
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