Cargando…

Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress

CONTEXT: The psychosocial stress has long been regarded as a significant pre-disposing factor for periodontal disease. The association between the periodontal disease and the neuroendocrine hormones has been observed. Chromogranin A (CgA) is supposed to link the activity of the neuroendocrine system...

Descripción completa

Detalles Bibliográficos
Autores principales: Reshma, Arunima Padmakumar, Arunachalam, Rajeev, Pillai, Jayakumar Kochu, Kurra, Sarath Babu, Varkey, Vini K., Prince, Mohanraj J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713754/
https://www.ncbi.nlm.nih.gov/pubmed/23869129
http://dx.doi.org/10.4103/0972-124X.113076
_version_ 1782277236782530560
author Reshma, Arunima Padmakumar
Arunachalam, Rajeev
Pillai, Jayakumar Kochu
Kurra, Sarath Babu
Varkey, Vini K.
Prince, Mohanraj J.
author_facet Reshma, Arunima Padmakumar
Arunachalam, Rajeev
Pillai, Jayakumar Kochu
Kurra, Sarath Babu
Varkey, Vini K.
Prince, Mohanraj J.
author_sort Reshma, Arunima Padmakumar
collection PubMed
description CONTEXT: The psychosocial stress has long been regarded as a significant pre-disposing factor for periodontal disease. The association between the periodontal disease and the neuroendocrine hormones has been observed. Chromogranin A (CgA) is supposed to link the activity of the neuroendocrine system to local and systemic immune functions and to be related to periodontitis. AIMS: The aim of this study was to determine the CgA levels in saliva and plasma in periodontal health and disease and to assess their potential relationship to periodontitis. SETTINGS AND DESIGNS: In this case-control study, the association between periodontal disease and stress marker has been assessed. MATERIALS AND METHODS: Sixty subjects were chosen for this study: With case group comprising of 30 subjects with chronic periodontitis and control group comprising of 30 healthy subjects. Salivary and plasma CgA levels were determined by ELISA technique. Clinical parameters included were plaque index, papillary bleeding index and clinical attachment loss and probing depth. Correlation analysis was calculated by independent sample t-test. RESULTS: Significantly higher CgA levels were found in saliva and plasma of patients with chronic periodontitis compared with healthy individuals (P < 0.05). No significant difference were observed between salivary and plasma CgA levels. CONCLUSIONS: The elevated level CgA in the plasma and saliva of subjects with stress induced chronic periodontitis has yielded insights into biological plausible association between the psychosocial stress and chronic periodontitis. Thus, our results suggest that CgA is a useful biomarker for evaluating at least in part the etiopathogenesis of periodontitis.
format Online
Article
Text
id pubmed-3713754
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-37137542013-07-18 Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress Reshma, Arunima Padmakumar Arunachalam, Rajeev Pillai, Jayakumar Kochu Kurra, Sarath Babu Varkey, Vini K. Prince, Mohanraj J. J Indian Soc Periodontol Original Article CONTEXT: The psychosocial stress has long been regarded as a significant pre-disposing factor for periodontal disease. The association between the periodontal disease and the neuroendocrine hormones has been observed. Chromogranin A (CgA) is supposed to link the activity of the neuroendocrine system to local and systemic immune functions and to be related to periodontitis. AIMS: The aim of this study was to determine the CgA levels in saliva and plasma in periodontal health and disease and to assess their potential relationship to periodontitis. SETTINGS AND DESIGNS: In this case-control study, the association between periodontal disease and stress marker has been assessed. MATERIALS AND METHODS: Sixty subjects were chosen for this study: With case group comprising of 30 subjects with chronic periodontitis and control group comprising of 30 healthy subjects. Salivary and plasma CgA levels were determined by ELISA technique. Clinical parameters included were plaque index, papillary bleeding index and clinical attachment loss and probing depth. Correlation analysis was calculated by independent sample t-test. RESULTS: Significantly higher CgA levels were found in saliva and plasma of patients with chronic periodontitis compared with healthy individuals (P < 0.05). No significant difference were observed between salivary and plasma CgA levels. CONCLUSIONS: The elevated level CgA in the plasma and saliva of subjects with stress induced chronic periodontitis has yielded insights into biological plausible association between the psychosocial stress and chronic periodontitis. Thus, our results suggest that CgA is a useful biomarker for evaluating at least in part the etiopathogenesis of periodontitis. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3713754/ /pubmed/23869129 http://dx.doi.org/10.4103/0972-124X.113076 Text en Copyright: © Journal of Indian Society of Periodontology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Reshma, Arunima Padmakumar
Arunachalam, Rajeev
Pillai, Jayakumar Kochu
Kurra, Sarath Babu
Varkey, Vini K.
Prince, Mohanraj J.
Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress
title Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress
title_full Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress
title_fullStr Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress
title_full_unstemmed Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress
title_short Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress
title_sort chromogranin a: novel biomarker between periodontal disease and psychosocial stress
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713754/
https://www.ncbi.nlm.nih.gov/pubmed/23869129
http://dx.doi.org/10.4103/0972-124X.113076
work_keys_str_mv AT reshmaarunimapadmakumar chromograninanovelbiomarkerbetweenperiodontaldiseaseandpsychosocialstress
AT arunachalamrajeev chromograninanovelbiomarkerbetweenperiodontaldiseaseandpsychosocialstress
AT pillaijayakumarkochu chromograninanovelbiomarkerbetweenperiodontaldiseaseandpsychosocialstress
AT kurrasarathbabu chromograninanovelbiomarkerbetweenperiodontaldiseaseandpsychosocialstress
AT varkeyvinik chromograninanovelbiomarkerbetweenperiodontaldiseaseandpsychosocialstress
AT princemohanrajj chromograninanovelbiomarkerbetweenperiodontaldiseaseandpsychosocialstress