Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection

Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that ident...

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Autores principales: Hingley-Wilson, Suzanne M., Casey, Rosalyn, Connell, David, Bremang, Samuel, Evans, Jason T., Hawkey, Peter M., Smith, Grace E., Jepson, Annette, Philip, Stuart, Kon, Onn Min, Lalvani, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2013
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713993/
https://www.ncbi.nlm.nih.gov/pubmed/23764343
http://dx.doi.org/10.3201/eid1907.130313
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author Hingley-Wilson, Suzanne M.
Casey, Rosalyn
Connell, David
Bremang, Samuel
Evans, Jason T.
Hawkey, Peter M.
Smith, Grace E.
Jepson, Annette
Philip, Stuart
Kon, Onn Min
Lalvani, Ajit
author_facet Hingley-Wilson, Suzanne M.
Casey, Rosalyn
Connell, David
Bremang, Samuel
Evans, Jason T.
Hawkey, Peter M.
Smith, Grace E.
Jepson, Annette
Philip, Stuart
Kon, Onn Min
Lalvani, Ajit
author_sort Hingley-Wilson, Suzanne M.
collection PubMed
description Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.
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spelling pubmed-37139932013-07-30 Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection Hingley-Wilson, Suzanne M. Casey, Rosalyn Connell, David Bremang, Samuel Evans, Jason T. Hawkey, Peter M. Smith, Grace E. Jepson, Annette Philip, Stuart Kon, Onn Min Lalvani, Ajit Emerg Infect Dis Dispatch Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance. Centers for Disease Control and Prevention 2013-07 /pmc/articles/PMC3713993/ /pubmed/23764343 http://dx.doi.org/10.3201/eid1907.130313 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Hingley-Wilson, Suzanne M.
Casey, Rosalyn
Connell, David
Bremang, Samuel
Evans, Jason T.
Hawkey, Peter M.
Smith, Grace E.
Jepson, Annette
Philip, Stuart
Kon, Onn Min
Lalvani, Ajit
Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection
title Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection
title_full Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection
title_fullStr Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection
title_full_unstemmed Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection
title_short Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection
title_sort undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713993/
https://www.ncbi.nlm.nih.gov/pubmed/23764343
http://dx.doi.org/10.3201/eid1907.130313
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