Cargando…

Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats

In this study, ethanolic extracts from Hericium erinaceum cultivated with Artemisia capillaris (HEAC) were assessed for their ability to lower the cholesterol levels of male Sprague-Dawley rats fed a high-fat diet. Rats were randomly subdivided into seven test groups. Each group contained eight rats...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Won-Sik, Kim, Young-Sun, Park, Byeoung-Soo, Kim, Jang-Eok, Lee, Sung-Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Mycology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714447/
https://www.ncbi.nlm.nih.gov/pubmed/23874132
http://dx.doi.org/10.5941/MYCO.2013.41.2.94
_version_ 1782277356029739008
author Choi, Won-Sik
Kim, Young-Sun
Park, Byeoung-Soo
Kim, Jang-Eok
Lee, Sung-Eun
author_facet Choi, Won-Sik
Kim, Young-Sun
Park, Byeoung-Soo
Kim, Jang-Eok
Lee, Sung-Eun
author_sort Choi, Won-Sik
collection PubMed
description In this study, ethanolic extracts from Hericium erinaceum cultivated with Artemisia capillaris (HEAC) were assessed for their ability to lower the cholesterol levels of male Sprague-Dawley rats fed a high-fat diet. Rats were randomly subdivided into seven test groups. Each group contained eight rats fed a high-fat diet during a growth period lasting 4 wk. Supplementation with the extracts was performed once a day for 2 wk after the high-fat diet. The control group (rats fed a high-fat diet) showed a high efficiency ratio (feed efficiency ratio) value compared to the normal group. Biochemical parameters, including total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and triglyceride (TG) levels dramatically increased in the control group compared to the normal group. High-density lipoprotein-cholesterol (HDL-c) content in the control group was also significantly lower relative to the normal group. Two positive control groups, treated with simvastatin and atorvastatin, had lowered TC, LDL-c, and TG levels, and increased HDL-c content compared to the control group. Treatment with the tested extracts, including HEAC, ethanolic extracts from Hericium erinaceum, and ethanolic extracts from Artemisia capillaris reduced TC, LDL-c, and TG levels and elevated HDL-c content in the hyperlipidemia rats. The atherogenic index and cardiac risk factor values for the HEAC-treated group were 0.95 and 1.95, respectively. Simvastatin- and atorvastatin-treated groups showed atherogenic index values of 1.56 and 1.69, respectively, and cardiac risk factor values of 2.56 and 2.69, respectively. These results show HEAC possesses an ability to cure hyperlipidemia in rats and may serve as an effective natural medicine for treating hyperlipidemia in humans.
format Online
Article
Text
id pubmed-3714447
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher The Korean Society of Mycology
record_format MEDLINE/PubMed
spelling pubmed-37144472013-07-19 Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats Choi, Won-Sik Kim, Young-Sun Park, Byeoung-Soo Kim, Jang-Eok Lee, Sung-Eun Mycobiology Research Article In this study, ethanolic extracts from Hericium erinaceum cultivated with Artemisia capillaris (HEAC) were assessed for their ability to lower the cholesterol levels of male Sprague-Dawley rats fed a high-fat diet. Rats were randomly subdivided into seven test groups. Each group contained eight rats fed a high-fat diet during a growth period lasting 4 wk. Supplementation with the extracts was performed once a day for 2 wk after the high-fat diet. The control group (rats fed a high-fat diet) showed a high efficiency ratio (feed efficiency ratio) value compared to the normal group. Biochemical parameters, including total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and triglyceride (TG) levels dramatically increased in the control group compared to the normal group. High-density lipoprotein-cholesterol (HDL-c) content in the control group was also significantly lower relative to the normal group. Two positive control groups, treated with simvastatin and atorvastatin, had lowered TC, LDL-c, and TG levels, and increased HDL-c content compared to the control group. Treatment with the tested extracts, including HEAC, ethanolic extracts from Hericium erinaceum, and ethanolic extracts from Artemisia capillaris reduced TC, LDL-c, and TG levels and elevated HDL-c content in the hyperlipidemia rats. The atherogenic index and cardiac risk factor values for the HEAC-treated group were 0.95 and 1.95, respectively. Simvastatin- and atorvastatin-treated groups showed atherogenic index values of 1.56 and 1.69, respectively, and cardiac risk factor values of 2.56 and 2.69, respectively. These results show HEAC possesses an ability to cure hyperlipidemia in rats and may serve as an effective natural medicine for treating hyperlipidemia in humans. The Korean Society of Mycology 2013-06 2013-06-30 /pmc/articles/PMC3714447/ /pubmed/23874132 http://dx.doi.org/10.5941/MYCO.2013.41.2.94 Text en © The Korean Society of Mycology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Choi, Won-Sik
Kim, Young-Sun
Park, Byeoung-Soo
Kim, Jang-Eok
Lee, Sung-Eun
Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats
title Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats
title_full Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats
title_fullStr Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats
title_full_unstemmed Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats
title_short Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats
title_sort hypolipidaemic effect of hericium erinaceum grown in artemisia capillaris on obese rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714447/
https://www.ncbi.nlm.nih.gov/pubmed/23874132
http://dx.doi.org/10.5941/MYCO.2013.41.2.94
work_keys_str_mv AT choiwonsik hypolipidaemiceffectofhericiumerinaceumgrowninartemisiacapillarisonobeserats
AT kimyoungsun hypolipidaemiceffectofhericiumerinaceumgrowninartemisiacapillarisonobeserats
AT parkbyeoungsoo hypolipidaemiceffectofhericiumerinaceumgrowninartemisiacapillarisonobeserats
AT kimjangeok hypolipidaemiceffectofhericiumerinaceumgrowninartemisiacapillarisonobeserats
AT leesungeun hypolipidaemiceffectofhericiumerinaceumgrowninartemisiacapillarisonobeserats