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Endocrine pancreatic development: impact of obesity and diet

During embryonic development, multipotent endodermal cells differentiate to form the pancreas. Islet cell clusters arising from the pancreatic bud form the acini tissue and exocrine ducts whilst pancreatic islets form around the edges of the clusters. The successive steps of islet differentiation ar...

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Autores principales: O'Dowd, Jacqueline F., Stocker, Claire J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714448/
https://www.ncbi.nlm.nih.gov/pubmed/23882220
http://dx.doi.org/10.3389/fphys.2013.00170
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author O'Dowd, Jacqueline F.
Stocker, Claire J.
author_facet O'Dowd, Jacqueline F.
Stocker, Claire J.
author_sort O'Dowd, Jacqueline F.
collection PubMed
description During embryonic development, multipotent endodermal cells differentiate to form the pancreas. Islet cell clusters arising from the pancreatic bud form the acini tissue and exocrine ducts whilst pancreatic islets form around the edges of the clusters. The successive steps of islet differentiation are controlled by a complex network of transcription factors and signals that influence cell differentiation, growth and lineage. A Westernized lifestyle has led to an increased consumption of a high saturated fat diet, and an increase in maternal obesity. The developing fetus is highly sensitive to the intrauterine environment, therefore any alteration in maternal nutrition during gestation and lactation which affects the in-utero environment during the key developmental phases of the pancreas may change the factors controlling β-cell development and β-cell mass. Whilst the molecular mechanisms behind the adaptive programming of β-cells are still poorly understood it is established that changes arising from maternal obesity and/or over-nutrition may affect the ability to maintain fetal β-cell mass resulting in an increased risk of type 2 diabetes in adulthood.
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spelling pubmed-37144482013-07-23 Endocrine pancreatic development: impact of obesity and diet O'Dowd, Jacqueline F. Stocker, Claire J. Front Physiol Physiology During embryonic development, multipotent endodermal cells differentiate to form the pancreas. Islet cell clusters arising from the pancreatic bud form the acini tissue and exocrine ducts whilst pancreatic islets form around the edges of the clusters. The successive steps of islet differentiation are controlled by a complex network of transcription factors and signals that influence cell differentiation, growth and lineage. A Westernized lifestyle has led to an increased consumption of a high saturated fat diet, and an increase in maternal obesity. The developing fetus is highly sensitive to the intrauterine environment, therefore any alteration in maternal nutrition during gestation and lactation which affects the in-utero environment during the key developmental phases of the pancreas may change the factors controlling β-cell development and β-cell mass. Whilst the molecular mechanisms behind the adaptive programming of β-cells are still poorly understood it is established that changes arising from maternal obesity and/or over-nutrition may affect the ability to maintain fetal β-cell mass resulting in an increased risk of type 2 diabetes in adulthood. Frontiers Media S.A. 2013-07-18 /pmc/articles/PMC3714448/ /pubmed/23882220 http://dx.doi.org/10.3389/fphys.2013.00170 Text en Copyright © 2013 O'Dowd and Stocker. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Physiology
O'Dowd, Jacqueline F.
Stocker, Claire J.
Endocrine pancreatic development: impact of obesity and diet
title Endocrine pancreatic development: impact of obesity and diet
title_full Endocrine pancreatic development: impact of obesity and diet
title_fullStr Endocrine pancreatic development: impact of obesity and diet
title_full_unstemmed Endocrine pancreatic development: impact of obesity and diet
title_short Endocrine pancreatic development: impact of obesity and diet
title_sort endocrine pancreatic development: impact of obesity and diet
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714448/
https://www.ncbi.nlm.nih.gov/pubmed/23882220
http://dx.doi.org/10.3389/fphys.2013.00170
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