Cargando…

Canagliflozin Lowers Postprandial Glucose and Insulin by Delaying Intestinal Glucose Absorption in Addition to Increasing Urinary Glucose Excretion: Results of a randomized, placebo-controlled study

OBJECTIVE: Canagliflozin, a sodium glucose cotransporter (SGLT) 2 inhibitor, is also a low-potency SGLT1 inhibitor. This study tested the hypothesis that intestinal canagliflozin levels postdose are sufficiently high to transiently inhibit intestinal SGLT1, thereby delaying intestinal glucose absorp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Polidori, David, Sha, Sue, Mudaliar, Sunder, Ciaraldi, Theodore P., Ghosh, Atalanta, Vaccaro, Nicole, Farrell, Kristin, Rothenberg, Paul, Henry, Robert R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714520/ https://www.ncbi.nlm.nih.gov/pubmed/23412078 http://dx.doi.org/10.2337/dc12-2391

Ejemplares similares

Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus
por: Polidori, David, et al.
Publicado: (2013)

Pharmacodynamic Effects of Canagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, from a Randomized Study in Patients with Type 2 Diabetes
por: Sha, Sue, et al.
Publicado: (2014)

Sotagliflozin Decreases Postprandial Glucose and Insulin Concentrations by Delaying Intestinal Glucose Absorption
por: Powell, David R, et al.
Publicado: (2019)

Pharmacodynamic differences between canagliflozin and dapagliflozin: results of a randomized, double‐blind, crossover study
por: Sha, S., et al.
Publicado: (2015)

OR22-5 Sotagliflozin Decreases Postprandial Glucose and Insulin by Delaying Intestinal Glucose Absorption
por: Powell, David, et al.
Publicado: (2019)

Changing the diabetes treatment paradigm from glucose control to cardiorenal protection
por: Ekanayake, Preethika, et al.
Publicado: (2021)

The effects of postprandial glucose and insulin levels on postprandial endothelial function in subjects with normal glucose tolerance
por: Suzuki, Kazunari, et al.
Publicado: (2012)

Effect of Canagliflozin on Renal Threshold for Glucose, Glycemia, and Body Weight in Normal and Diabetic Animal Models
por: Liang, Yin, et al.
Publicado: (2012)

Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels
por: Xu, Jiesi, et al.
Publicado: (2014)

Cardiorenal protective effects of canagliflozin in CREDENCE according to glucose lowering
por: Charytan, David M, et al.
Publicado: (2023)

Postprandial Glucose: Marker or Risk Factor?
por: Avogaro, Angelo
Publicado: (2011)

Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants
por: Devineni, Damayanthi, et al.
Publicado: (2015)

Canagliflozin alleviates high glucose-induced peritoneal fibrosis via HIF-1α inhibition
por: Wang, Jian, et al.
Publicado: (2023)

Canagliflozin-associated Diabetic Ketoacidosis with Lower-than-anticipated Glucose Levels
por: Vadi, Sonali, et al.
Publicado: (2017)

Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes
por: Polidori, David, et al.
Publicado: (2014)

Dose-Ranging Effects of Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, as Add-On to Metformin in Subjects With Type 2 Diabetes
por: Rosenstock, Julio, et al.
Publicado: (2012)

Effect of Cinnamon Tea on Postprandial Glucose Concentration
por: Bernardo, Maria Alexandra, et al.
Publicado: (2015)

A Glucose-Only Model to Extract Physiological Information from Postprandial Glucose Profiles in Subjects with Normal Glucose Tolerance
por: Eichenlaub, Manuel M., et al.
Publicado: (2021)

Insulin enhances renal glucose excretion: relation to insulin sensitivity and sodium-glucose cotransport
por: Ferrannini, Ele, et al.
Publicado: (2020)

Effect of Apple Consumption on Postprandial Blood Glucose Levels in Normal Glucose Tolerance People versus Those with Impaired Glucose Tolerance
por: Inoue, Yutaka, et al.
Publicado: (2022)

Postprandial Blood Glucose can be less than Fasting Blood Glucose and this is not a Laboratory Error
por: Pant, Vivek, et al.
Publicado: (2019)

Hyperleptinaemia and its Association with Postprandial Hypertriglyceridemia and Glucose Intolerance
por: Aslam, M., et al.
Publicado: (2021)

Mathematical Modeling of Renal Tubular Glucose Absorption after Glucose Load
por: De Gaetano, Andrea, et al.
Publicado: (2014)

There is always glucose in normal urine: unspecific excretion associated with serum glucose and glomerular filtration rate
por: Li, Tianqi, et al.
Publicado: (2022)

Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes
por: Ciaraldi, Theodore P., et al.
Publicado: (2016)

Effects of Type 2 Diabetes on Insulin Secretion, Insulin Action, Glucose Effectiveness, and Postprandial Glucose Metabolism
por: Basu, Ananda, et al.
Publicado: (2009)

Performance of Fasting Plasma Glucose and Postprandial Urine Glucose in Screening for Diabetes in Chinese High-risk Population
por: Yang, Bing-Quan, et al.
Publicado: (2015)

Effects of Meal Fructose/Glucose Composition on Postprandial Glucose Appearance and Hepatic Glycogen Synthesis in Healthy Subjects
por: Barosa, Cristina, et al.
Publicado: (2021)

Salivary Glucose Concentration and Excretion in Normal and Diabetic Subjects
por: Jurysta, Cedric, et al.
Publicado: (2009)

Euglycemic Diabetic Ketoacidosis With Prolonged Glucosuria Associated With the Sodium-Glucose Cotransporter-2 Canagliflozin
por: Kelmenson, Daniel A., et al.
Publicado: (2017)

Short‐term effects of canagliflozin on glucose and insulin responses in insulin dysregulated horses: A randomized, placebo‐controlled, double‐blind, study
por: Lindåse, Sanna, et al.
Publicado: (2023)

Intra‐ and inter‐subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co‐transporter 2 inhibitor canagliflozin
por: Polidori, David, et al.
Publicado: (2018)

Chilled Potatoes Decrease Postprandial Glucose, Insulin, and Glucose-dependent Insulinotropic Peptide Compared to Boiled Potatoes in Females with Elevated Fasting Glucose and Insulin
por: Patterson, Mindy A, et al.
Publicado: (2019)

Na(+)-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion
por: Gorboulev, Valentin, et al.
Publicado: (2012)

Glucose Absorption in Gestational Diabetes Mellitus During an Oral Glucose Tolerance Test
por: Anderwald, Christian, et al.
Publicado: (2011)

Eating vegetables before carbohydrates improves postprandial glucose excursions
por: Imai, S, et al.
Publicado: (2013)

Postprandial Glucose as a Risk Factor for Elevated Intraocular Pressure
por: Wu, Chen-Jung, et al.
Publicado: (2016)

Exercise after You Eat: Hitting the Postprandial Glucose Target
por: Erickson, Melissa L., et al.
Publicado: (2017)

Effect of Mizagliflozin on Postprandial Plasma Glucose in Patients With Functional Constipation
por: Fukudo, Shin, et al.
Publicado: (2019)

Postprandial Glucose Spikes, an Important Contributor to Cardiovascular Disease in Diabetes?
por: Hanssen, Nordin M. J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ijo9fkurkl285h6o92t2qb7n10