Flecainide reduces Ca(2+) spark and wave frequency via inhibition of the sarcolemmal sodium current

AIMS: Ca(2+) waves are thought to be important in the aetiology of ventricular tachyarrhythmias. There have been conflicting results regarding whether flecainide reduces Ca(2+) waves in isolated cardiomyocytes. We sought to confirm whether flecainide inhibits waves in the intact cardiomyocyte and to...

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Autores principales: Sikkel, Markus B., Collins, Thomas P., Rowlands, Christina, Shah, Mit, O'Gara, Peter, Williams, Alan J., Harding, Sian E., Lyon, Alexander R., MacLeod, Kenneth T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Articles: Spotlight on T-Tubules and Ryanodine Receptor Microdomain Signalling in Cardiac Hypertrophy and Failure
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714924/
https://www.ncbi.nlm.nih.gov/pubmed/23334259
http://dx.doi.org/10.1093/cvr/cvt012

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