CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B cell signaling and activation

C-src tyrosine kinase, Csk, physically interacts with the intracellular phosphatase Lyp (PTPN22) and can modify the activation state of downstream Src kinases, such as Lyn, in lymphocytes. We identified an association of Csk with systemic lupus erythematosus (SLE) and refined its location to an intr...

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Detalles Bibliográficos
Autores principales: Manjarrez-Orduño, Nataly, Marasco, Emiliano, Chung, Sharon A., Katz, Matthew S., Kiridly, Jenna F., Simpfendorfer, Kim R., Freudenberg, Jan, Ballard, David H., Nashi, Emil, Hopkins, Thomas J., Graham, Deborah S Cunninghame, Lee, Annette T., Coenen, Marieke J. H., Franke, Barbara, Swinkels, Dorine W., Graham, Robert R., Kimberly, Robert P., Gaffney, Patrick M., Vyse, Timothy J., Behrens, Timothy W., Criswell, Lindsey A., Diamond, Betty, Gregersen, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715052/
https://www.ncbi.nlm.nih.gov/pubmed/23042117
http://dx.doi.org/10.1038/ng.2439

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