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Variations within Class-A β-Lactamase Physiochemical Properties Reflect Evolutionary and Environmental Patterns, but not Antibiotic Specificity

The bacterial enzyme β-lactamase hydrolyzes the β-lactam ring of penicillin and chemically related antibiotics, rendering them ineffective. Due to rampant antibiotic overuse, the enzyme is evolving new resistance activities at an alarming rate. Related, the enzyme's global physiochemical proper...

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Detalles Bibliográficos
Autores principales:	Verma, Deeptak, Jacobs, Donald J., Livesay, Dennis R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715408/ https://www.ncbi.nlm.nih.gov/pubmed/23874193 http://dx.doi.org/10.1371/journal.pcbi.1003155

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