Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8(+) T-Cell Exhaustion

The type I interferons (IFN-Is) are critical not only in early viral control but also in prolonged T-cell immune responses. However, chronic viral infections such as those of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) in humans and lymphocytic choriomeningitis virus (LCMV) in mic...

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Detalles Bibliográficos
Autores principales: Lee, Myeong Sup, Park, Chan Hee, Jeong, Yun Hee, Kim, Young-Joon, Ha, Sang-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715418/
https://www.ncbi.nlm.nih.gov/pubmed/23874199
http://dx.doi.org/10.1371/journal.ppat.1003478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715418/
https://www.ncbi.nlm.nih.gov/pubmed/23874199
http://dx.doi.org/10.1371/journal.ppat.1003478

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