The Role of Multiple Marks in Epigenetic Silencing and the Emergence of a Stable Bivalent Chromatin State

We introduce and analyze a minimal model of epigenetic silencing in budding yeast, built upon known biomolecular interactions in the system. Doing so, we identify the epigenetic marks essential for the bistability of epigenetic states. The model explicitly incorporates two key chromatin marks, namel...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Swagatam, Sengupta, Anirvan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715441/
https://www.ncbi.nlm.nih.gov/pubmed/23874171
http://dx.doi.org/10.1371/journal.pcbi.1003121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715441/
https://www.ncbi.nlm.nih.gov/pubmed/23874171
http://dx.doi.org/10.1371/journal.pcbi.1003121

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