Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis

Endoplasmic reticulum (ER) stress represents an early pathological event in amyotrophic lateral sclerosis (ALS). ATF4 is a key ER stress transcription factor that plays a role in both adaptation to stress and the activation of apoptosis. Here we investigated the contribution of ATF4 to ALS. ATF4 def...

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Detalles Bibliográficos
Autores principales: Matus, Soledad, Lopez, Estefanía, Valenzuela, Vicente, Nassif, Melissa, Hetz, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715499/
https://www.ncbi.nlm.nih.gov/pubmed/23874395
http://dx.doi.org/10.1371/journal.pone.0066672

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