Turnover of Amyloid Precursor Protein Family Members Determines Their Nuclear Signaling Capability

The amyloid precursor protein (APP) as well as its homologues, APP-like protein 1 and 2 (APLP1 and APLP2), are cleaved by α-, β-, and γ-secretases, resulting in the release of their intracellular domains (ICDs). We have shown that the APP intracellular domain (AICD) is transported to the nucleus by...

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Detalles Bibliográficos
Autores principales: Gersbacher, Manuel T., Goodger, Zoë V., Trutzel, Annette, Bundschuh, Diana, Nitsch, Roger M., Konietzko, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715505/
https://www.ncbi.nlm.nih.gov/pubmed/23874953
http://dx.doi.org/10.1371/journal.pone.0069363

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