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Psychosis-Proneness and Neural Correlates of Self-Inhibition in Theory of Mind

Impaired Theory of Mind (ToM) has been repeatedly reported as a feature of psychotic disorders. ToM is crucial in social interactions and for the development of social behavior. It has been suggested that reasoning about the belief of others, requires inhibition of the self-perspective. We investiga...

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Autores principales: van der Meer, Lisette, Groenewold, Nynke A., Pijnenborg, Marieke, Aleman, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715518/
https://www.ncbi.nlm.nih.gov/pubmed/23874445
http://dx.doi.org/10.1371/journal.pone.0067774
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author van der Meer, Lisette
Groenewold, Nynke A.
Pijnenborg, Marieke
Aleman, André
author_facet van der Meer, Lisette
Groenewold, Nynke A.
Pijnenborg, Marieke
Aleman, André
author_sort van der Meer, Lisette
collection PubMed
description Impaired Theory of Mind (ToM) has been repeatedly reported as a feature of psychotic disorders. ToM is crucial in social interactions and for the development of social behavior. It has been suggested that reasoning about the belief of others, requires inhibition of the self-perspective. We investigated the neural correlates of self-inhibition in nineteen low psychosis prone (PP) and eighteen high PP subjects presenting with subclinical features. High PP subjects have a more than tenfold increased risk of developing a schizophrenia-spectrum disorder. Brain activation was measured with functional Magnetic Resonance Imaging during a ToM task differentiating between self-perspective inhibition and belief reasoning. Furthermore, to test underlying inhibitory mechanisms, we included a stop-signal task. We predicted worse behavioral performance for high compared to low PP subjects on both tasks. Moreover, based on previous neuroimaging results, different activation patterns were expected in the inferior frontal gyrus (IFG) in high versus low PP subjects in self-perspective inhibition and simple response inhibition. Results showed increased activation in left IFG during self-perspective inhibition, but not during simple response inhibition, for high PP subjects as compared to low PP subjects. High and low PP subjects showed equal behavioral performance. The results suggest that at a neural level, high PP subjects need more resources for inhibiting the self-perspective, but not for simple motor response inhibition, to equal the performance of low PP subjects. This may reflect a compensatory mechanism, which may no longer be available for patients with schizophrenia-spectrum disorders resulting in ToM impairments.
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spelling pubmed-37155182013-07-19 Psychosis-Proneness and Neural Correlates of Self-Inhibition in Theory of Mind van der Meer, Lisette Groenewold, Nynke A. Pijnenborg, Marieke Aleman, André PLoS One Research Article Impaired Theory of Mind (ToM) has been repeatedly reported as a feature of psychotic disorders. ToM is crucial in social interactions and for the development of social behavior. It has been suggested that reasoning about the belief of others, requires inhibition of the self-perspective. We investigated the neural correlates of self-inhibition in nineteen low psychosis prone (PP) and eighteen high PP subjects presenting with subclinical features. High PP subjects have a more than tenfold increased risk of developing a schizophrenia-spectrum disorder. Brain activation was measured with functional Magnetic Resonance Imaging during a ToM task differentiating between self-perspective inhibition and belief reasoning. Furthermore, to test underlying inhibitory mechanisms, we included a stop-signal task. We predicted worse behavioral performance for high compared to low PP subjects on both tasks. Moreover, based on previous neuroimaging results, different activation patterns were expected in the inferior frontal gyrus (IFG) in high versus low PP subjects in self-perspective inhibition and simple response inhibition. Results showed increased activation in left IFG during self-perspective inhibition, but not during simple response inhibition, for high PP subjects as compared to low PP subjects. High and low PP subjects showed equal behavioral performance. The results suggest that at a neural level, high PP subjects need more resources for inhibiting the self-perspective, but not for simple motor response inhibition, to equal the performance of low PP subjects. This may reflect a compensatory mechanism, which may no longer be available for patients with schizophrenia-spectrum disorders resulting in ToM impairments. Public Library of Science 2013-07-18 /pmc/articles/PMC3715518/ /pubmed/23874445 http://dx.doi.org/10.1371/journal.pone.0067774 Text en © 2013 van der Meer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
van der Meer, Lisette
Groenewold, Nynke A.
Pijnenborg, Marieke
Aleman, André
Psychosis-Proneness and Neural Correlates of Self-Inhibition in Theory of Mind
title Psychosis-Proneness and Neural Correlates of Self-Inhibition in Theory of Mind
title_full Psychosis-Proneness and Neural Correlates of Self-Inhibition in Theory of Mind
title_fullStr Psychosis-Proneness and Neural Correlates of Self-Inhibition in Theory of Mind
title_full_unstemmed Psychosis-Proneness and Neural Correlates of Self-Inhibition in Theory of Mind
title_short Psychosis-Proneness and Neural Correlates of Self-Inhibition in Theory of Mind
title_sort psychosis-proneness and neural correlates of self-inhibition in theory of mind
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715518/
https://www.ncbi.nlm.nih.gov/pubmed/23874445
http://dx.doi.org/10.1371/journal.pone.0067774
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